Vitamin A、D、E And Recurrent Respiratory Tract Infections In Children:A Correlation Study

BackgroundIn recent years,the incidence of respiratory tract infection in children has been increasing year by year with the existence of atmospheric environment,pollution and other reasons.According to domestic reports,the daily outpatients with recurrent respiratory tract infection(RRTIs)accounted for about 20-30%of the daily outpatients with respiratory tract infection.RRTIs are characterized by complex etiology,long course,greater difficulty in treatment and easy recurrence.Therefore,it is very necessary to carry out the study of repeated respiratory tract infection in children.Therefore,it is very issue important to study the causes of RRTIs in children,particularly the causes of RRTIs,which to reduce the incidence rate of RRTIs in children.Vitamin A,vitamin D and vitamin E are important organic elements in the body,and have an important effect on the body’s metabolism,growth and development.In recent years,many scholars have increased the research and reports on vitamins A,D,and E and children’s growth and development.However,the levels of vitamins A,D,and E in different countries,regions,and age groups are also different.The effects of vitamins A,D,and E on children’s immunity are a hot topic in recent years.At present,no reports on the correlation of the level difference of vitamin A,D and E in different age groups with respiratory tract infection at home and abroad.In particular,there were few studies on the relationship between vitamin E and children with repeated respiratory infections.ObjectiveOur work will identify the levels of vitamin A,D and E in different age groups and the correlation with RRTIs in children,and aim to provide effective evidences in reducing the incidence of RRTIs in children,as well as developping a standardized program for testing indicators.Methods1.200 children with RRTIs were investigated in pediatrics of Anyang People’s Hospital. All cases were divided into three age groups:6 months-3 years old,3-6 years old and 6-14years old,and meanwhile,211 children without RRTIs and 172 healthy children from outpatient medical examination department were compared to control groups.The range of age recruited children was 6 months-14 year old.2.Blood samples of all participants were collected in the early morning in a room without sunlight.Standard products of Sigma Company were used to determine vitamin A,D and E by reversed-phase high performance liquid chromatography.3.Statistical processing SPSS 22.0 was used for statistical analysis of data.Chi-square test(χ~2)was used for comparison of gender composition among the groups,and one-way analysis of variance were used for comparison of mean,mean±standard deviation(x±s)after normal distribution of measurement data,P<0.05 was statistically significant.Results1.Serum levels of vitamin A,D and E with RRTIs and without RRTIs were significantly lower than those in normal children(P<0.05).Serum levels of vitamin A,D and E in RRTIs group were significantly lower than those in without RRTIs group(all P<0.05).2.There were no significant differences in serum vitamin A and vitamin E levels between the children of the RRTIs group and the without RRTIs group at the ages of 6months-3,3-6 and 6-14(P﹥0.05).However,there were statistically significant differences in vitamin D levels(all P<0.05).Furthermore,vitamin D levels declined with age.3.There is no statistically significant difference in serum vitamin A levels at the ages of6 months-3,3-6,6-14(P﹥0.05).There were statistically significant differences in vitamin D and E levels(P<0.05).Furthermore,vitamin D and vitamin E levels declined with age.4.There is a significant difference between vitamin A,D and E in the three age groups respectively(P<0.05).Among them,the serum vitamin A,D,and E levels were the highest in the normal control group,followed by the non-RRTIs group and the lowest in the RRTIs group.Conclusions1.Decreased levels of serum vitamins A,D,and E may be a predisposing factors for children with RRTIs.2.Supplementation of vitamins A,D and E is essential for inducing the incidence of RRTIs in all age groups,especially for school-age children with vitamin D and infants with vitamin A.3.Healthy children have a high incidence of vitamin A and vitamin D deficiency,while vitamin E deficiency is rare.Most healthy children have adequate vitamin E levels,but they still need vitamin A and vitamin D supplements.