A Retrospective Study Of Diagnosis And Treatment Of Hypopharyngeal Cancer Synchronous With Primary Cancer Of Upper Digestive Tract

ObjectiveThis retrospective study was designed to analyze the characteristics and diagnosis of hypopharyngeal and esophageal double primary cancer and explore the treatment strategy of hypopharyngeal and esophageal[1,2]double primary cancer.MethodsThe clinical data of 49 patients with double primary cancer of hypopharynx and esophagus admitted to Qilu Hospital of Shandong University from February 2017 to September 2019 were retrospectively analyzed.The scope of tumor involvement was determined by preoperative gastroscopy,enhanced CT and other auxiliary examination methods,and the appropriate treatment was selected.Postoperative survival was statistically analyzed according to the classification of related risk factors.Result49 patients were analyzed,and the overall 3-years survival rate of all patients was 49%.Patients were followed up for 3 years,with a median age（65）55₇5).The longest follow-up time was 37 months.Of the patients,there were 5 cases of death due to postoperative complications by liver metastasis and lung metastasis,17 cases were evaluated for hypopharyngeal tumor who could not preserve laryngeal function total laryngectomy total esophagus,resection,and total tubular gastric replacement,was performed,in all 17 cases.There were 5 cases of hypopharyngeal and esophageal resection with preserving laryngeal cancer were used.There were 8 cases of hypopharyngeal carcinoma resection with laryngeal function preservation and gastroscopic esophageal lesion.The remaining 19 cases were treated with radiotherapy,due to physical intolerance for a surgical operation.There were 5 cases of death due to postoperative complications of the liver and lung metastasis for the long term treatment and the follow up was about 37 months,there is a classification of pathological and the survival.The 3-year overall survival rate of the patients was 49%.ConclusionPatients with hypopharyngeal cancer are prone to develop simultaneous esophageal cancer.It is of great significance for early detection of multiple primary cancers to screen patients with hypopharyngeal cancer and esophageal cancer.A stratified treatment strategy takes into account the treatment and clinical stages of two kinds of single primary cancer to achieve a holistic treatment,which can be considered as the choice of clinical treatment.