Levels And Significance Of Plasma S(P)RR Level In Patients With Coronary Atherosclerotic Heart Disease

BackgroundAt present,coronary heart disease,which is the main pathological process of atherosclerosis,remains the main cause of incidence rate and mortality.Early diagnosis and diagnosis of high-risk patients and strengthening intervention are of great clinical significance.They can effectively reduce mortality and improve the prognosis of patients and improve their quality of life.RAS plays an important role in the pathology and development of coronary heart disease.Prorenin receptor(PRR),a member of RAS family,is widely expressed in various tissues,including heart,blood vessel,kidney and brain.Its activation leads to the increase of angiotensin II(AngⅡ)production on cell surface and triggers the blood vessel dependent intracellular pathway related to auxin signaling.More and more evidence shows that PRR is involved in the pathophysiology of cardiovascular disease,especially the occurrence of end-stage organ injury.However,the changes of PRR concentration in patients with coronary heart disease and whether it is involved in the pathological process of coronary heart disease are still unknown.The purpose of this study is to detect the plasma level of sPRR in patients with coronary heart disease and healthy controls,to clarify the changes of PRR level in patients with coronary heart disease,and to explore the factors influencing the level of PRR,and to determine whether SPRR is an independent risk factor for coronary heart disease,so as to provide theoretical basis for early screening of high-risk patients and early intervention,And through early screening of high-risk patients to reduce the clinical burden.Objective1.Investigate the changes of plasma soluble(pro)renin receptor in patients with coronary atherosclerotic heart disease.2.Investigate the factors influencing soluble(pro)renin receptor in patients with coronary atherosclerotic heart disease.3.Investigate whether soluble(pro)renin receptor is an independent predictor of coronary atherosclerotic heart disease,in order to screen of high-risk patients.MethodPatients with coronary atherosclerotic heart disease were selected as the study object,and healthy subjects were selected as the normal control group in the same period.The age,sex,height,weight,BMI and other general information of the selected patients were collected,and the fasting venous blood of the selected patients in the morning was collected.Serum soluble PRR levels were measured by standard laboratory methods,including hypersensitive troponin T(HsTnT),B-type natriuretic peptide precursor(pro-BNP),fasting blood glucose,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglyceride(TG),creatinine(Scr),urea nitrogen(BUN)and creatine kinase isoenzyme(CKMB).T test and chi square test were used to compare the differences of general data,biochemical indexes and plasma s(P)RR levels between coronary heart disease group and control group.The coronary heart disease group was divided into ACS group and SAP group.Correlation analysis was used to analyze the related factors affecting the concentration of plasma s(P)RR.Logistic regression was used to analyze whether plasma s(P)RR was a predictor of coronary artery disease severity.SPSS 19.0 software was used for statistical analysis of the research data,and graphpad prism 6.0 was used for mapping,with significant level of P<0.05.Result1.There was no significant difference in sex,age,height,weight and other general data between the CHD group and the control group.There were significant differences in the history of drinking,diabetes,hypertension and fasting blood glucose,BNP,CKMB,Hs TnT,LVEF,high density lipoprotein between the CHD group and the control group(P<0.05).2.The plasma s(P)RR in the CHD group was significantly higher than that in the control group and the difference was statistically significant(P<0.05).The patients with coronary heart disease were divided into ACS group and SAP group.It was found that the plasma s(P)RR in ACS group was significantly higher than that in control group(P<0.05).There was no significant difference in plasma s(P)RR between),ACS group and SAP group.Although the plasma s(P)RR in SAP group was higher than that in SAP group,the difference was not statistically significant.3.The level of plasma s(P)RR in patients with coronary artery disease involving three branches(n=30)was higher than that in patients with coronary artery disease involving one branch(n=28)and two branches(n=30).There was significant difference between three branches group and one branch group(P<0.05).4.The level of s(P)RR in patients with coronary heart disease was positively correlated with the history of diabetes,Gensini score and the number of diseased coronary arteries,and the correlation coefficients were 0.27(P<0.01),0.24(P<0.01)and 0.27(P<0.01).5.Plasma s(P)RR is an independent predictor of the degree of coronary artery stenosis.Conclusion:1.The level of plasma soluble(pro)rennin receptor[s(P)RR]in patients with coronary atherosclerotic heart disease was significantly higher than that in normal subjects,especially in patients with acute coronary syndrome.There was no significant difference in plasma soluble(pro)rennin receptor levels between patients with stable angina pectoris and normal subjects.2.The level of plasma s(P)RR in patients with coronary atherosclerotic heart disease was positively correlated with the history of diabetes,Gensini score and the number of diseased coronary arteries.3.Plasma s(P)RR can be used as an independent predictor of the severity of coronary stenosis in patients with coronary atherosclerotic heart disease.