Clinical Study On The Treatment Of Endometriosis Infertility With Dingkundan Combined With Laparoscopy

Objective:To observe the clinical effect of Dingkundan combined with laparoscopy in the treatment of endometriosis infertility,and to provide theoretical basis for clinical application.Methods:Strictly in accordance with the inclusion criteria and exclusion criteria,collected in November 2019 to August 2020 in Shanxi Province hospital see a doctor in line with the blood stasis type endometriosis infertility patients with 60 cases,according to the medical order,using the random number table method is divided into the treatment group(set of combined laparoscopic treatment)and control group(pure laparoscopic treatment),30 cases of treatment group patients with postoperative use of Dan,the three month is 1 treatment course,continuous dosing 2 course of treatment.Two groups of patients healed before(laparoscopic surgery),line(after 6 months),respectively,after cure serum glucose class antigen 125(carbohydrate antigen 125,CA125),vascular endothelial growth factor(vascular endothelial growth factor,VEGF),insulin-like growth factor 1(insulin-like growth factor 1,IGF-1)blood tests,observed before and after treatment in patients with clinical overall curative effect and TCM syndrome total curative effect,The total score of TCM syndrome,the changes of serum CA125,VEGF,IGF-1 and pregnancy outcome.All the data involved in the experiment were statistically analyzed by SPSS25.0software,and conclusions were drawn based on the statistical results.Results:(1)Comparison of overall clinical efficacy between the two groups: the total effective rate of 86.67% in the treatment group was superior to 56.67% in the control group,with statistical significance(P < 0.05).(2)The levels of serum CA125,VEGF and IGF-1 in 2 groups were decreased after treatment compared with before treatment,with statistical significance(P < 0.05);After treatment,the levels of serum CA125,VEGF and IGF-1 in the treatment group were lower than those in the control group,and the difference was statistically significant(P < 0.05),indicating that the treatment group was superior to the control group in reducing the levels of serum CA125,VEGF and IGF-I.(3)After treatment,TCM syndrome scores in 2 groups were lower than before treatment,the difference was statistically significant(P < 0.05);The comparison of TCM syndrome scores between the two groups after treatment showed that the treatment group was better than the control group,and the difference was statistically significant(P < 0.05).After treatment,the total efficacy of TCM in 2 groups was better than that before treatment,the difference was statistically significant(P < 0.05).After treatment,the total efficacy of TCM in 2 groups was better than that in the control group,the difference was statistically significant(P < 0.05).(4)Comparison of pregnancy outcomes between the two groups: there were 14 cases of pregnancy in the treatment group and 6 cases in the control group,and the difference in pregnancy rate between the two groups was statistically significant(P < 0.05),indicating that the treatment group was significantly better than the control group in terms of pregnancy rate.Conclusion: 1.The clinical efficacy of Dingkundan combined with laparoscopy in the treatment of infertility patients with endometriosis was significantly better than that of laparoscopy alone;2.Dingkundan combined with laparoscopic treatment can effectively improve patients’ TCM syndromes,reduce serum levels of CA125,VEGF and IGF-I,and improve the pregnancy rate of patients.