Clinical Analysis On Xiyanping Injection In The Treatment Of Mild Bacterial Enteritis In Children

ObjectiveTo investigate the effect,liver and renal functions,intestinal flora imbalance and hospitalization cost of Xiyanping injection in the treatment of children suffered from mild bacterial enteritis,so as to provide the clinical evidence to reational drug using for pediatrician.MethodsA total of 66 children diagnosed with"bacterial enteritis"who were hospitallized in Shenyang Children’s Hospital from September 2019 to December 2020 were collected and randomly divided into 2 groups,that is treatment group(group A)with 35case,control group(group B)with 31 case.Xiyanping injection was used in group A and cefodizime used in group B,besides the same rountine treatment was used both in2 groups.The blood rountine was done by using flow cytometry+2-D scattering method,CRP was tested by Quik Read go method,liver and kidney function was tested by continuous monitoring method and Gastrointestinal Microbiome was tested by microscope oil lens.Compare treatment 3 to 7 days after two groups of children with fever,vomiting,dehydration,diarrhea and other symptoms,inflammatory indicators(white blood cell count,neutrophils percentage,lymphocytes percentage,C-reactive protein)and main indicators of liver and kidneys(alanine transaminase,glutamic oxalacetic transaminase,serum total bilirubin,blood urea nitrogen,creatinine,)and the change of intestinal flora dividing and total hospitalization costs were observed and counted.SPSS 22.0 software was adopted in data processing,measurement data was represented by mean±standard deviation((?)±S),t test or t’test were used depending on whether the comparison between the two groups conforms to the normal distribution and homoscedasticity,χ~2 test was used in enumeration data and ranked data,P<0.05 is of statistical significance.The difference was of statistical significance P<0.05.Results1.66 cases were collected with 37 boys and 29 girls.there were no significant differences between Xiyanping treatment group(group A,with 20 boys and 15 girls,average age:32.54±18.43 months)and cefedizime control group(group B with 17boys and 14 girl girls,average age:33.68±20.62 months)in those items.2.Which include sex,age,fever or not,body temperature on admission,course of disease,degree of dehydration,degree results of acid base disorder,degree results of defecation routine,degrees of intestinal dysbacteriosis,major indicators of blood routine,CRP,ALT,AST,TBil,BUN,Cr,before treatment.3.There was no significant difference in the duration of vomiting,dehydration,diarrhea and length of stay in hospital between group A and B after treatment.But the significantly shorter antipyretic time was found in group A(t=-2.164,P=0.034).Through comparation,it was found that,8 cases were markedly,21 effective,and 6ineffective in group A(total effective rate was 82.86%),while 7 markedly,18 effective,and 6 ineffective in group B(total effective rate was 80.65%);the total effective rate was no significant difference between the two groups.4.A vertical comparison of the major indicators of the blood routine and CRP of the two groups showed significant difference before and after the treatment.(P>0.05 in both groups).But the major indicators of the liver and renal functions(ALT、AST、TBil、BUN、Cr)of the children in two goups suffering from bacillary enteritis showed no significant difference before and after the treatment.5.The changement about the degrees of intestinal dysbacteriosis was also observed before and after treatment,it was found that 12 cases were improved,21unchanged,and 2 aggravated in group A,as well as,13 improved,15unchanged,and 3aggravated in group B after treatment.There was no significant difference between the two drugs in the effect on intestinal flora imbalance.6.Meanwhile,the hospitalization expenses of group A was significantly lower than that of group B(t=-3.278,P=0.002).Conlusions1.Compared with Cefodizime Sodium injection,the Xiyanping injection has the same effect in treating children suffering from mild bacterial enteritis but has significant antipyretic effectiveness.No obvious abnormalities on liver and renal functions were observed within seven days’treatment.2.The effect of Xiyanping injection on intestinal flora imbalance is similar to that of cefodizime sodium injection.3.It was less expensive to use Xiyanping injection to treat treat children’s mild bacterial enteritis than cefodizime in the case of the same degree of illness.