Correlation Between Monocyte/high-density Lipoprotein Cholesterol Ratio And Subclinical Target Organ Damage In Young And Middle-aged Patients With Essential Hypertension

Objective: To investigate the relationship between the subclinical target organ damage(TOD)and the monocyte-to-high-density lipoprotein cholesterol ratio(MHR)in the young and middle-aged patients with essential hypertension(EH).Method: The clinical data of 294 young and middle-aged EH patients were retrospectively analyzed.Collect subclinical TOD related indicators and general clinical data,biochemical indicators,echocardiography,carotid ultrasound,etc.of the selected subjects,and calculate the left ventricular mass index(LVMI)from this.According to LVMI,estimated glomerular filtration rate(e GFR),and carotid ultrasound,the selected subjects were grouped and the differences between the groups were compared.Correlation analysis of the correlation between MHR and early heart,kidney,and blood vessel damage in young and middle-aged EH patients.Multivariate logistic regression analysis MHR leads to the risk of subclinical TOD in young and middle-aged EH patients.Result: Univariate analysis showed:(1)MHR,White blood cell count(WBC),Neutrophil count(NEUT),Monocyte count(MONO),Lymphocyte count(LY),blood uric acid,Cystatin C(Cys C)in the LVH group were significantly higher than those patients in the NLVH group[(0.47± 0.11)vs(0.33± 0.12)],[(6.94± 1.84)vs(6.01± 1.56))],[(4.13± 1.38)vs(3.61 ± 1.26)],[(0.51 ± 0.11)vs(0.40 ± 0.11)],[(2.08 ± 0.66)vs(1.85 ± 0.51)],[(388.54 ± 107.06)vs(354.43 ± 94.13)],[0.83(0.68,0.98)vs0.72(0.61,0.88)],while Total cholesterol(TC)and high-density lipoprotein cholesterol(HDL-C)were lower in the LVH group[4.25(3.62,4.87)vs4.57(3.95,5.25)],[1.06(0.94,1.22)vs 1.27(1.07,1.47)](all P<0.05).(2)Compared with the normal renal function group,the waist circumference,body mass index(BMI),MHR,WBC,NEUT,MONO,LY,serum creatinine(SCr),triacylglycerol(TG),blood uric acid,Cys C of the abnormal renal function group is higher [(95.25± 9.73)vs(92.40± 9.61)],[(27.52± 4.00)vs(26.34 ± 3.18)],[(0.43 ± 0.12)vs(0.29 ± 0.12)],[(6.59 ± 1.78)vs(5.93 ±1.52)],[(3.91±1.37)vs(3.59±1.24)],[(0.47±0.10)vs(0.38±0.11)],[(2.01± 0.59)vs(1.82 ± 0.53)],[(87.54 ± 17.23)vs(81.95 ± 17.21)],[1.81(1.20,2.81)vs 1.63(1.11,2.56)],[(384.86±103.62)vs(338.41±87.31)],[0.82(0.68,0.96)vs 0.69(0.59,0.84)],while TC and HDL-C were lower in the abnormal renal function group[4.27(3.66,5.01)vs.4.68(4.03,5.54)],[1.10(0.97,1.29)vs 1.34(1.12,1.52)](all P<0.05).(3)Compared with the non-carotid atherosclerosis group,the waist circumference,smoking rate,MONO,MHR,Cys C,gender,age of the carotid atherosclerosis group is higher[(95.15±9.30)vs(92.81 ± 10.18)],[81(62.8%)vs 48(37.2%)],[(0.46 ± 0.11)vs(0.41 ±0.12)],[(0.41±0.13)vs(0.34±0.13)],[0.82(0.67,0.96)vs 0.72(0.61,0.87)],[109(61.6%)vs 68(38.4%)],[(53.25 ± 10.34)vs(49.34 ± 10.86)],while HDL-C[1.11(0.99,1.34)vs 1.27(1.07,1.48)] was lower in the non-carotid atherosclerosis group(all P<0.05).Correlation analysis showed that MHR was positively correlated with LVMI and c IMT(r =0.381,0.258,all P<0.01),and negatively correlated with e GFR(r =-0.347,P<0.01).Binary Logistic regression shows that after adjusting for confounding factors affecting heart,kidney,and blood vessel damage,MHR was still the result of left ventricular hypertrophy,early renal dysfunction,and carotid atherosclerosis in young and middle-aged EH patients(OR=1.089,1.101,1.035,95%CI: 1.068-1.130,1.067-1.135,1.013-1.057,P<0.001)independent risk factors.In addition,with the increase in the number of TOD,the greater the risk of MHR(arbitrary one,two,or three target organ damage OR=0.971,1.044,1.081).Conclusion: MHR is related to heart,kidney,and blood vessel damage in young and middle-aged EH patients,and MHR increases with the severity of TOD.It is an independent risk factor for early heart,kidney,and blood vessel damage in this population.