Effect Of Vitamin D Level On The Treatment Of Primary Ulcerative Colitis

Objective: To investigate the correlation and clinical significance between vitamin D levels and treatment outcomes of Incipient ulcerative colitis(UC);Methods: 114 patients with UC were selected and diagnosed in our hospital from June 2017 to June2020.Among them,38 patients were vitamin D deficient and 76 patients were normal vitamin D at the beginning of treatment,all of whom were prescribed treatment for 12 weeks.Test indicators(white blood cell,erythrocyte sedimentation rate(ESR),hemoglobin,platelet(PLT)count,C-reactive protein(CRP)level,and modified Mayo score)of the initial condition before the normative treatment were compared between the2 groups,and the degree of change of the relevant test indexes(white blood cells,erythrocyte sedimentation rate(ESR),hemoglobin,platelet(PLT)count,C-reactive protein(CRP)level)and the extent of change in the modified Mayo score were further compared before and after the normative treatment for 12 weeks.Results: The pretreatment CRP,ESR,and modified Mayo scores were significantly higher and hemoglobin significantly lower in the vitamin D normal group than in the deficient group,all with statistically significant differences(P < 0.05),whereas the pretreatment white blood cell and platelet counts were not significantly different between the vitamin D normal group and the vitamin D deficient group.At the same time,the degree composition of the initial illness was also compared between the two groups,and the difference was statistically significant(P < 0.05),with the mild UC composition higher in the vitamin D normal group than in the deficient group and the severe UC composition lower than in the deficient group.The extent of change in white blood cell,ESR,hemoglobin,and PLT counts was significantly greater in the vitamin D normal group than in the deficient group,all with significant differences(P < 0.05),whereas CRP levels and modified Mayo score were not significantly different between the vitamin D normal group and the deficient group.Conclusions: Vitamin D levels are associated with the extent of the disease at the initial onset of UC and the effects of initial treatment;UC patients with normal vitamin D at the beginning of treatment had better outcomes than vitamin D deficient patients.