Vitamin D Levels And Disease Conditions In Patients With Ulcerative Colitis Degree Of Correlation Studies

Objective:Ulcerative colitis is an immune-mediated disease affecting the gastrointestinal tract.Vitamin D has been shown to modulate many immune diseases,and this study aimed to investigate the correlation between vitamin D levels and the severity of the disease in patients with UC.Methods:A total of 102 patients diagnosed as primary UC in the First Affiliated Hospital of Xinjiang Medical University from January 2020 to January 2023 were selected,and data on gender,age,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),Mayo score,and vitamin D level were collected.To compare the differences in clinical symptoms and clinical indicators between UC patients with different vitamin D levels.To compare the difference in vitamin D levels between UC patients with different conditions and different lesion sites.Multiple linear regression analysis was also performed to find independent predictors of the degree of condition in UC patients.Results:UC patients in the vitamin D insufficiency group were more likely to have hematochezia,severe urgency and abdominal pain,which were statistically significant(P<0.05).The age,body mass index,ESR,CRP,and Mayo score were significantly higher than those in the vitamin D insufficiency group,and the differences were statistically significant(P<0.05).Vitamin D levels in UC patients with severe disease and large lesions were significant(P<0.05).Deficiency of vitamin D levels and increased body mass index predicted severe severity of UC patients and were statistically significant(P<0.05).Conclusion:Vitamin D level indirectly affects the clinical manifestations,test index,degree of condition and extent of lesions in UC patients.Vitamin D levels can negatively predict the degree of disease condition in UC patients.Body mass index positively predicts the degree of disease condition in UC patients.