| Objective:Evaluation of the clinical efficacy of two anticoagulants in continuous renal replacement therapy for patients with acute kidney injury(parameters related to safety and efficacy during treatment).Methods: Intensive care unit of xinjiang uygur autonomous region people’s hospital were retrospectively analyzed in December 2020 and December 2015,CRRT treatment in patients with AKI,conform to the inclusion criteria,80 cases of patients with AKI as the research object,on the basis of local sodium citrate anticoagulation in a different way is divided into group of 40 cases(observation group),the whole body ordinary heparin anticoagulant group of 40 cases(control group).1.Separate statistics;General information for both groups included(gender,APACHEⅡ score,age,length of ICU stay,total length of hospital stay,primary disease).2.Relevant parameters during CRRT treatment in the two groups;Liver function before and after the two groups of patients treated with CRRT(total bilirubin,total protein,albumin,aspertate aminotransferase,alanine aminotransferase),kidney(creatinine and urea nitrogen values),uric acid,blood coagulation function(PT,PA,INR,APTT),hemoglobin,red blood cell count,platelet count,lactic acid and electrolyte(sodium,potassium,chloride,calcium,bicarbonate root The child).3.28-day mortality rate of patients.4.Service life of the filter.5.Statistical methods: SPSS23.0 software was used in this study for detection and analysis.Measurement data were expressed as mean ± standard deviation(x±s)and t test.The rate of count data(%)was used,χ~2 was used;The case fatality rate at 28 days was analyzed using a survival curve.P < 0.05 indicated statistical significance.Results:1.There were no significant differences in sex ratio,APACHEⅡ score,age,time in ICU,total length of hospital stay,and primary disease of CRRT patients between the two groups(P > 0.05).2.Before CRRT treatment,there were no significant differences in PT,PA,APTT,PLT and INR between 2 groups(P > 0.05).After CRRT treatment,there were significant differences in PA,APTT and PT between the two groups(P < 0.05).3.There were no significant differences in total protein,total bilirubin,glutamic-oxalacetic transaminase,alanine transaminase and albumin between the two groups before and after CRRT treatment(all P < 0.05).4.There were significant differences in creatinine,urea nitrogen and uric acid in sodium citrate group before and after CRRT treatment(P < 0.05);Urea nitrogen,creatinine and uric acid in heparin group before and after CRRT treatment were statistically significant(P < 0.05).There were no significant differences in creatinine,uric acid and urea nitrogen between the two groups before and after CRRT treatment(P >0.05).5.The comparison of hemoglobin before and after CRRT between the two groups was not statistically significant(P>0.05);The hemoglobin values of sodium citrate group before and after CRRT treatment were different,with statistical significance(P <0.05).There were significant differences in the hemoglobin values of heparin sodium CRRT before and after treatment(P < 0.05).6.There was a significant difference in the filter life between the two groups(P <0.05);7.The 28-day fatality rate of 2 groups was analyzed by Kaplan-Meier curve,χ~2=1.603,P>0.05,no statistical significance.Conclusion:1.Both of the two different anticoagulant methods can ensure that the metabolic creatinine and urea nitrogen in the body can be effectively removed during the treatment of CRRT.2.Compared with systemic heparin and local citrate anticoagulant,sodium citrate group significantly extended the filter life.3.Heparin sodium anticoagulant has a greater effect on coagulation function than citrate anticoagulant.4.Both groups of anticoagulant methods have an effect on hemoglobin,making the hemoglobin decrease after dialysis. |
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