Clinical Effect Analysis Of Salvia Miltiorrhiza Ligustrazine Combined With Compound Anthracine In Treatment Of NAION

Purpose:To study the clinical effect and related influencing factors of Danshen Tligustrazine combined with Compound Anthocyanine in the treatment of patients with nonarteriammatory anterior ischemic optic neuropathy.Methods:A total of 110 inpatients who were diagnosed as "non-arteriammatory anterior ischemic optic neuropathy" in the Department of Ophthalmology of the First Affiliated Hospital of Dali University from January 1,2015 to December 31,2020 were collected.Inclusion criteria: the symptoms and signs met the diagnostic criteria in the Expert Consensus on the Diagnosis and Treatment of Non-Arteriammatory Anterior Ischemic Optic Neuropathy in China(2015).Did not receive any drug therapy 1 month prior to the treatment in this study;High patient compliance,informed and consented to the study;The patient lived in western Yunnan for a long time and actively cooperated with follow-up visits.Exclusion criteria: all symptoms and signs of the patient did not meet the diagnostic criteria;Patients with severe organ disease were unable to participate in the study;Suffer from other ocular diseases that may affect the fundus examination in the study,such as corneal leukoplakia and severe cataract;Low compliance.Expansion criteria: the patients in the study had severe adverse drug reactions and had to suspend medication;Patients in the study decided to drop out;The patient was lost to follow-up.Treatment group: 55patients(64 eyes),male 27 patients(49.1%),female 28 patients(50.9%),age 55.04±10.78 years old,average course of disease 37.12±34.76 days,were treated with saltiorrhiza chuliguzine combined with compound antherine.Control group: 55 patients(61 eyes),male 29 patients(52.7%),female 26 patients(47.3%),age 57.03±12.40 years old,average course of disease 30.80±30.64 days,were treated with compound anisocyanine only.The visual acuity,optic fiber layer thickness and visual field of the two groups before and after treatment were compared and analyzed.Results:1.Before treatment,the comparison of age,gender,body mass index and systemic underlying diseases between the two groups showed P>0.05,with no statistical significance.2.Before treatment,the visual acuity,retinal nerve fiber layer thickness and visual field of 2 groups of patients were compared,P>0.05,the difference was not statistically significant.3.After treatment,visual acuity,retinal nerve fiber layer thickness and average visual field defect were improved in both groups(P<0.05).The differences were statistically significant.4.After treatment,visual acuity difference,retinal nerve fiber layer difference and mean visual field defect difference were compared between the two groups,the treatment group was better than the control group,P<0.05,the difference was statistically significant.5.After treatment,the total effective rate of the treatment group was 89.1%,and the total effective rate of the control group was 80.3%,P=0.013,the difference was statistically significant.Conclusion:1.Salvia miltiorrhiza ligustrazine combined with compound camphorylline had a better effect on NAion than single drug.2.After the combined treatment,the patients’ visual acuity,RNFLT and visual field MD value were improved and improved to a better degree.The combination of salvia miltiorrhiza ligustrazine and compound antherine in the treatment of NAion is worthy of clinical promotion and application.