Study On The Distribution Characteristics Of TCM Syndromes Of Nonalcoholic Fatty Liver Disease Complicated With Type 2 Diabetes Mellitus

Research objective:1.To unveil the distribution regular pattern of TCM syndromes in NAFLD complicated with T2DM.2.To explore the correlation between TCM syndrome and general data and objective indicators of TCM syndrome in NAFLD complicated with T2DM and to provide certain basis for microscopic differentiation.Research method:1.Using cross-section study,228 sufferers with NAFLD and T2DM whom comes from The First Affiliated Hospital of Yunnan TCM University from December 2019 to December 2020 were studied,the general data(gender,age,BMI and etc.),TCM four examination materials and assays(blood biochemistry,glucose and etc.)as well as related information were collected.2.SPPSS 24.0 was employed to conduct R type cluster analysis on four examination materials whose proportion was over 5%,TCM syndrome of NAFLD complicated with T2DM was summed up.Throughχ2 test,Chi-square analysis,non-parameter test and establishment of regression models as well as other methods,correlation between different TCM syndromes and general data and assays of NAFLD complicated with T2DM were explored.Research results:1.General data of sufferers with NAFLD complicated with T2DM were as follows:the average age of sufferers was 50.71±9.42 years,proportion of sufferers whose age was within the interval of 55 to 65 years of age was the greatest(39.5%),a higher incidence was observed among males between 35 and 45 years of age(P<0.05).Proportion of sufferers whose BMI was between 24 to 28kg/m~2was the greatest.2.Syndrome characters of NAFLD complicated with T2DM were as follows:there were 10 syndromes whose emergence frequency was greatest,fatigue has the highest emergence frequency(84.6%),the second is dry mouth(45.6%),others syndromes were mouth bitterness(36.4%),abdominal distension(30.3%),queasy(32.5%),thamuria(31.1%),deep-colored urine(30.7%),khando(29.4%),dizzy(26.3%)and loss of appetite(22.8%);the most common condition of tongue and pulse were red tongue(34.2%),yellow greasy fur(31.6%)and rolling quickly pulse(22.8%).The four examination materials of sufferers with NAFLD complicated with T2DM was finally clustered into 5 syndrome-types,these were phlegmatic hygromas impedes syndrome-type,hygrothermal thwart syndrome-type,liver-yin and kidney-yin feeble syndrome-type,liver inhibit and spleen feeble syndrome-type,stagnant blood and heat internal block syndrome-type.The distribution regular pattern of TCM syndrome-types was as follows:hygrothermal thwart syndrome-type(31.6%)>phlegmatic hygromas impedes syndrome-type(21.5%)>liver inhibit and spleen feeble syndrome-type(18.4%)>liver-yin and kidney-yin feeble syndrome-type(16.7%)>stagnant blood and heat internal block syndrome-type(11.8%).3.There were general differences in data of syndromes of NAFLD complicated with T2DM:in phlegmatic hygromas impedes syndrome-type,the male was the predominant;in liver-yin and kidney-yin feeble syndrome-type,the female was the predominant(P<0.05);sufferers with liver-yin and kidney-yin feeble syndrome-type has the oldest average age(P<0.05);BMI was the highest in phlegmatic hygromas impedes syndrome-type,and BMI was the second highest in hygrothermal thwart syndrome-type(P<0.05).4.In general,there were differences in assays of NAFLD complicated with T2DM syndromes:the GGT level of hygrothermal thwart syndrome-type was higher than that of liver-yin and kidney-yin feeble syndrome-type(P<0.05);the HDL-C level of sufferers with hygrothermal thwart syndrome-type or phlegmatic hygromas impedes syndrome-type was lower than that of liver inhibit and spleen feeble syndrome-type or liver-yin and kidney-yin feeble syndrome-type at large(P<0.05);the SUA of sufferers with hygrothermal thwart syndrome-type or phlegmatic hygromas impedes syndrome-type was obviously higher than that of liver inhibit and spleen feeble syndrome-type or liver-yin and kidney-yin feeble syndrome-type(P<0.05).Research conclusion:1.In sufferers with NAFLD complicated with T2DM,the proportion of hygrothermal thwart syndrome-type(31.6%)and phlegmatic hygromas impedes syndrome-type(21.5%)was the highest.The distribution regular pattern of syndrome-types was as follows:hygrothermal thwart syndrome-type>phlegmatic hygromas impedes syndrome-type>liver inhibit and spleen feeble syndrome-type>liver-yin and kidney-yin feeble syndrome-type>stagnant blood and heat internal block syndrome-type.2.The two organs as liver and spleen are involved in the morbidity of NAFLD complicated with T2DM,the fundamental pathogenesis is liver Qi stagnation,spleen loss of health,phlegmatic hygromas and stagnant blood be produced,blocked in the body for long time and being transformed into heat,the main pathological risk factors were moistures.3.Syndromes of NAFLD complicated with T2DM were closely correlated with gender,age,BMI,GGT,HDL-C,SUA as well as other risk factors.Middle-age female patients are more likely to show liver-yin and kidney-yin feeble syndrome-type.Overweight and obese sufferers are more likely to show hygrothermal thwart syndrome-type and phlegmatic hygromas impedes syndrome-type.In addition,sufferers with hygrothermal thwart syndrome-type and phlegmatic hygromas impedes syndrome-type are often associated with metabolic disorders of HDL-C and SUA.