Study On The Correlation Between IGF-1 And Glucose And Lipid Metabolism And Microvascular Disease In Type 2 Diabetes Mellitus

Background Purpose:With the rapid improvement of people’s living standards and economic development,the number of people suffering from type 2diabetes keeps increasing.If blood glucose is not well controlled,it will seriously affect the metabolism of sugar and lipid of patients,and seriously threaten many tissues and organs in the body,and induce microvascular diseases.IGF-1 is a peptide hormone with an insulin-like effect.95% of IGF-1 is produced dependent on GH and regulates GH with negative feedback.Studies have shown that IGF-1 can promote the uptake of amino acids,glucose and free fatty acids in tissues,and promote the synthesis of fat,protein and glycogen in the body,thereby reducing blood sugar.In various clinical trials,IGF-1 has been found to be of great clinical value in increasing insulin sensitivity and reducing insulin resistance in patients with diabetes.Moreover,it is directly involved in the growth and development of CD4 and CD8,delaying the occurrence of diabetes by regulating immunity.Other studies have shown that IGF-1 is involved in the occurrence and development of chronic complications of diabetes,but the specific mechanism remains unclear.In this study,general data and biochemical indexes of patients meeting the criteria were retrospectively collected and randomly sampled,and the correlation between IGF-1 and glucose and lipid metabolism and microvascular lesions of type 2 diabetes was obtained by appropriate statistical methods,in order to provide relevant evidence for the disease monitoring,disease diagnosis and clinical treatment of type 2 diabetes.Methods:A total of 94 patients with type 2 diabetes diagnosed in the endocrinology outpatient department and inpatient department of China-Japan Friendship Hospital of Jilin University from April 2019 to January 2021 were randomly selected.According to the experimental report of nuclear medicine department in our hospital,the IGF-1 normal group(n=55)was set within its normal range,and the IGF-1 decreased group(n=39)was set below its minimum value.General information of the study population was recorded: gender,age,height,weight,BMI,disease duration,smoking history,alcohol consumption history;Biochemical indicators: fasting blood glucose,2-hour postprandial blood glucose,glycosylated hemoglobin,insulin growth factor 1,triglyceride,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,urinary microalbumin/creatinine,and whether or not accompanied by microvascular disease.The correlation between the decrease of IGF-1 and the indicators and the risk factors were analyzed.Results:(1)Compared with IGF-1 decreased group,age,BMI,FPG,PBG,Hb A1 c and TG of IGF-1 normal group were higher than those of normal group,and ACR was lower than that of normal group,with statistical significance(P < 0.05).The detection rate of TC,HDL-C,LDL-C and microvascular lesions had no statistical significance.(2)Binary Logistic regression model showed that the increase of age,BMI and PBG was correlated with the decrease of IGF-1,and might be an independent influencing factor.Conclusion:(1)Glucolipid levels in the normal IGF-1 group were lower than those in the decreased IGF-1 group,and the decrease of IGF-1 was correlated with the increase of Glucolipid levels,suggesting that IGF-1may improve Glucolipid metabolism.(2)ACR of IGF-1 normal group was higher than that of IGF-1decreased group,suggesting that IGF-1 may be involved in the occurrence and development of microvascular lesions.