Clinical Study Of Jiawei Wuhu Decoction In The Treatment Of Adult Community-acquired Pneumonia(Non-severe)with Phlegm-heat Obstruction

Research purpose:Through a comparative study between the control group and the treatment group,the clinically effective Jiawei Wuhu Decoction was used as the research object,and the degree of fever,frequency of coughing,sputum volume and color quality,lung signs,chest imaging,The total score of TCM syndromes is the main observation index,white blood cell count(WBC),C-reactive protein(CRP),platelet-lymphocyte ratio(PLR),procalcitonin(PCT),interleukin-6(IL-6),Interleukin-10(IL-10)is the secondary observation index,and the eleven items of liver and kidney function are the safety indexes.To evaluate its efficacy,it is a better way to treat adult community-acquired pneumonia(non-Severe cases)provide objective evidence,and ultimately achieve the goal of alleviating the suffering of patients and shortening the course of disease.Research method:We selected 80 hospitalized patients with adult community-acquired pneumonia(non-severe)phlegm-heat choking lung syndrome from November 1,2019 to January 31,2021 in the pulmonary disease ward of Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Randomly divided into two groups of 40 cases each.Patients in the control group were treated with piperacillin and tazobactam sodium 2.5g/bid combined with azithromycin 0.5g/qd intravenously for anti-infection,ambroxol hydrochloride 30mg/tid orally for phlegm,and if necessary(body temperature≥39℃),take Sanli Pain(compound paracetamol tablets Ⅱ)450mg oral fever.The treatment plan for patients in the treatment group is as follows:Western medicine treatment is consistent with the control group,and an additional dose of Jiawei Wuhu Decoction is taken every morning and evening.A total of 1 course of treatment,namely 10 days,was observed in the study.This project intends to treat the main symptoms of fever,coughing,expectoration,chest tightness,dry mouth,constipation,wheezing,loss of appetite,and lung rales in the two groups before treatment and on the 3rd,7th,and 10th days after treatment.The symptoms are scored,and the scores of the main symptoms,the scores of the secondary symptoms,and the total scores of TCM syndromes are calculated respectively,and the trend of changes is observed,and the comprehensive therapeutic effect is evaluated after treatment.Before and after the treatment,the white blood cell count(WBC),platelet-lymphocyte ratio(PLR),C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)and interleukin-10(IL-10)was measured to evaluate its clinical efficacy.During the treatment process,pay attention to the patient’s adverse reactions,and measure the patient’s liver and kidney function before and after treatment as safety indicators.Result:1.After the treatment of patients in the treatment group and the control group,the scores of each individual syndrome decreased significantly,and the treatment was effective.Among them,compared with the control group,the scores of cough,sputum,chest pain,dry mouth,dry stool,abdominal distension,and loss of appetite after treatment in the treatment group decreased more significantly than before treatment.After analysis,the results are statistically significant(P<0.01).2.Compared with the previous time point,the scores of primary symptoms,secondary symptoms,and TCM syndrome total scores of patients in the treatment group and the control group on the 3rd,7th,and 10th days were significantly reduced;Compared with the control group,the score was lower on the 7th and 10th day,and statistical analysis showed that the difference was significant(P<0.01).3.According to the comprehensive efficacy evaluation standard,the effective rate of the control group was 81.09%,and the effective rate of the treatment group was 94.74%,the difference was statistically significant(P<0.05).4.Compared with before treatment after treatment(day 10),the levels of WBC,PLR,and CRP of the two groups of patients were significantly reduced(P<0.01);among them,the levels of the above three indicators after treatment in the treatment group were significantly lower than those in the control group.Analysis shows that the difference is significant(P<0.01).Compared with before treatment,after treatment(on the 10th day),the levels of PCT and IL-6 in the two groups were significantly reduced,and the levels of IL-10 were significantly increased(P<0.01);Among them,the three serological indicators in the treatment group changed more significantly than those in the control group after treatment,and the difference was statistically significant(P<0.01).5.During the treatment,there were no serious adverse reactions in the two groups of patients,and there was no statistical difference in the incidence of adverse reactions-(P>0.05).Conclusion:On the basis of conventional Western medicine treatment,combined application of Jiawei Wuhu Decoction to treat adult community-acquired pneumonia(non-severe)with phlegm-heat obstructing lung syndrome can quickly and effectively improve the clinical symptoms of patients with fever,cough,sputum,chest pain,etc.Compared with the treatment of western medicine alone,the relief rate is faster and the clinical effect is better.At the same time,Jiawei Wuhu Decoction can also reduce the expression of inflammatory factors in the blood,inhibit excessive inflammation,and promote the clinical recovery of patients.This topic affirmed the safety and reliability of the clinical application of Jiawei Wuhu Decoction,and provided an objective basis for the further clinical use and promotion of Jiawei Wuhu Decoction in the future.