| Objective:To explore the feasibility of repetitive Transcranial Magnetic Stimulation(r TMS)with high frequency and low frequency,To investigate the effect of repetitive Transcranial Magnetic Stimulation(r TMS)on depressive symptoms and cognitive function in patients with late-life depression,and to compare the effect of repetitive Transcranial Magnetic Stimulation(r TMS)with different stimulation frequencies on depressive symptoms and cognitive function in patients with late-life depression,so as to seek a more scientific treatment for late-life depression.Methods:92 elderly patients with depression who were hospitalized and outpatients in Qingdao mental health center from January to December 2020 were selected.After signing the informed consent,they were randomly divided into three groups:control group(31 cases),low frequency treatment group(29cases)and high frequency treatment group(32 cases).The control group was only treated with escitalopram,while the two treatment groups were treated with different frequency r TMS.The data were collected by general condition questionnaire,Hamilton Depression Scale(HAMD-24)and repeatable complete neuropsychological state measurement scale(RBANS),and whether there were serious adverse reactions during the experiment was observed.After8 weeks of treatment,HAMD-24 and RBANS were used to score again.Results: 1.There was no statistically significant difference in age,gender,education level,course of disease,marital status and long-term residence,hamd-24 score and RBANS score among the three groups(P >0.05).2.Before and after treatment,the total score and factor score of hamd-24 in the three groups were lower than before treatment,and the scores in the control group were lower than those in the magnetic stimulation treatment group,but there was no significant difference between the high frequency magnetic stimulation treatment group and the low frequency magnetic stimulation treatment group.3.Before and after treatment,the total score of RBANS and each factor score of the two treatment groups showed an upward trend,but there was no statistical difference between the two groups;the rising range of each score of the control group was less than that of the two treatment groups,with statistical difference.At the end of the 8th week,the total and factor scores of RBANS in the high frequency treatment group and the low frequency treatment group were higher than those in the control group,with statistical difference;however,there was no statistical difference between the high frequency treatment group and the low frequency treatment group.4.There were no serious adverse reactions in the two treatment groups and the drug group,with good tolerance and no serious adverse events.5.Correlation analysis showed that the total score of depression,anxiety / somatization were negatively correlated with the total score of cognitive function and each factor score(P < 0.01);the factor score of cognitive impairment was negatively correlated with the total score of cognitive function,immediate memory,visual span,speech function,attention and delayed memory(P < 0.01 or P < 0.05);the block factor score was negatively correlated with the total score of cognitive function There was a significant negative correlation between the scores of anxiety,immediate memory,visual span,attention and delayed memory(P < 0.01 or P < 0.05);there was a significant negative correlation between the scores of despair and the total scores of cognitive function,visual span,speech function and delayed memory(P < 0.01 or P < 0.05).6.Multiple linear regression analysis showed that group,education level,weight,anxiety / somatization,HAMD total score and other factors entered the regression equation with the total score of RBANS and the score of each factor as the dependent variable(P < 0.01).Conclusion: 1.The effect of repetitive transcranial magnetic stimulation(r TMS)combined with escitalopram in the treatment of senile depression is more significant than that of drug therapy alone,but there is no relationship between the improvement and r TMS stimulation frequency.2.Repetitive transcranial magnetic stimulation(r TMS)combined with escitalopram can significantly improve the cognitive function of elderly patients with depression,which is more effective than drug therapy alone,but the long-term effect remains to be observed.3.High frequency and low frequency repetitive transcranial magnetic stimulation is well tolerated and safe in the treatment of senile depression.Repetitive transcranial magnetic stimulation may be an effective treatment for senile depression. |
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