Study On Cognitive Function And Attentional Bias Of High Frequency Repetitive Transcranial Magnetic Stimulation In Patients With First-episode Depression

Objectives:To investigate the intervention effect of high frequency repetitive transcranial magnetic stimulation on cognitive function and attentional bias in patients with firstepisode depression.Methods:Study protocol: Seventy-five first-onset depression patients from the outpatient and inpatient department of psychosomatic medicine of the First Affiliated Hospital of Nanchang University from January 2020 to December 2020 were divided into study group and control group by random number table method,with 37 cases in study group and 38 cases in control group.Patients in both groups received sertraline(Zolofol),a class of 5-HT reuptake inhibitors(SSRIs),and the specific dosage was adjusted by the attending physician according to the actual situation of the patients.The study group received high frequency repetitive transcranial magnetic stimulation in addition to the drug therapy for 4 weeks,5 times a week,while the control group received pseudo stimulation in addition to the drug therapy for 4 weeks,5 times a week.Two groups of patients in the intervention before and after the intervention of 4 weeks using Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA),cognitive function assessment(attachment test,test,Hopkins words learning tests,wechsler memory scale,simple visual spatial memory test,category fluency test,continuing the same matching operation,Stroop color word)were used to evaluate the severity of anxiety and depression and the impaired cognitive function of patients.Standardified pointdetection paradigm was used to explore whether patients had negative attentional bias.SPSS25.0 was used for statistical analysis of the data,and P<0.05 indicated a statistically significant difference.Research results:1.The team with the control group,respectively,in the information processing speed,attention/alertness,working memory,learning,visual words,words,color and color word score before and after the intervention on the difference had statistical significance(P < 0.05),in the information processing speed,working memory,color word score projects,such as team to improve the effect is obviously better than that of control group,There was statistical significance(P < 0.05).2.group and control group in positive word correctly,neutral accuracy,negative word correct,positive reaction,neutral reaction,negative reaction on indicators such differences were statistically significant before and after intervention(P < 0.05),the team to improve the effect is not significantly better than control group,there was no statistically significant difference(P > 0.05).3.There was a statistically significant difference between the study group and the control group in HAMA scale scores before and after intervention(P < 0.05),but the improvement effect of anxiety symptoms in the study group was not significantly better than that in the control group,and the difference was not statistically significant(P >0.05).There was a statistically significant difference in HAMD scores before and after intervention(P < 0.05),and the improvement effect of depression symptoms in the study group was significantly better than that in the control group,with a statistically significant difference(P < 0.05).4.When the posttest,the team information processing speed and working memory scores are higher than the control group,the difference has statistical significance(P >0.05),in learning,visual attention/alertness,words,words,color,color word score,positive word correctly,neutral accuracy,negative word correct,positive reaction,neutral reaction time,reaction time,the negative word There was no significant difference between the two groups(P BBB 0 0.05).Research conclusions:1.High-frequency repetitive transcranial magnetic stimulation can effectively improve the level of cognitive function in patients with first-episode depression;2.Antidepressants can improve negative attentional bias in patients with firstepisode depression,while high frequency repetitive transcranial magnetic stimulation does not significantly improve negative attentional bias in patients with first-episode depression.3.High frequency repetitive transcranial magnetic stimulation can effectively improve the depressive symptoms of patients with depression,but the improvement of anxiety symptoms is not obvious.