Correlationbetween Cystatin C And Type 2 Diabetesmellitus Complicatedwith Nonalcoholicfattyliver Disease

Objective:To analyze the level of cystatin C(CysC)and its influencing factors in patients with type 2 diabetes mellitus(T2DM)combined with non-alcoholic fatty liver disease(NAFLD)in Yanbian area,as well as the risk factors of T2 DM combined with NAFLD,so as to provide a theoretical basis for the diagnosis and treatment of T2 DM combined with NAFLD.Research objects and methods: A total of 80 cases receiving physical examination in the Department of Physical Examination were selected as the healthy control group(NC group),and 394 cases of T2 DM hospitalized in the Department of Endocrinology of a Affiliated Hospital from January 2019 to December 2020 were randomly selected.The general data and biochemical indicators of the patients were collected,and the presence of fatty liver was determined by ultrasound examination and other techniques.The research subjects were divided into T2 DM group and T2DM+NAFLD group.According to the liver function abnormalities in the selected studies,the T2DM+NAFLD group was divided into the simple fatty liver group and the steatohepatitis group.At the same time,age,gender,ethnicity,and blood pressure were recorded,and the levels of CysC,fasting blood glucose(FPG),glycated hemoglobin(Hb A1c),high density lipoprotein cholesterol(HDL),low density lipoprotein cholesterol(LDL),total cholesterol(TC),triglycerides(TG),aspartate aminotransferase(AST),alanine aminotransferase(ALT),glutamyl transpeptidase(GGT),and body mass index(BMI)in each group were detected.SPSS26.0 statistical software was used for analysis.Results:1.For the comparison of general clinical data among the three groups,there was no significant difference in age among NC group,T2 DM group and T2DM+NAFLD group(P> 0.05).Compared between the sexes in the NC group,the T2 DM group and the T2DM+NAFLD group,and compared with the NC group,the proportion of women in the T2DM+NAFLD group was higher than that of men,and the difference was statistically significant(P< 0.05).As for the comparison of other clinical indicators among the three groups,compared with the NC group,the levels of CysC,SBP,BMI,TC,TG,FPG and Hb A1 c in the T2 DM group were higher than those in the NC group,and the difference was statistically significant(P< 0.05).The levels of CysC,SBP,DBP,BMI,TC,TG,AST,ALT,GGT,LDL,FPG and Hb A1 c in the T2DM+NAFLD group were higher than those in the NC group,while HDL level was lower than that in the NC group(P< 0.05).The levels of CysC,DBP,BMI,TC,TG,LDL,AST,ALT,GGT,FPG and Hb A1 c in the T2DM+NAFLD group were higher than those in the T2 DM group(P< 0.05).There was no statistical difference in various clinical indicators between the Korean and Han nationalities in the T2DM+NAFLD group(P> 0.05).The age of the group with simple fatty liver was higher than that of the group with fatty hepatitis,and the difference was statistically significant(P< 0.05).2.Results of CysC correlation analysis: CysC was positively correlated with age,GGT,and SBP.Results of CysC influencing factor analysis: age,GGT,and SBP were the influencing factors of CysC.3.Regression analysis of influencing factors in patients with T2DM+NAFLD showed that CysC,age,TG,LDL,BMI,ALT and FPG were the influencing factors for T2 DM complicated with NAFLD.Conclusion:1.CysC,age,blood lipids,BMI,transaminases,and blood glucose may increase the risk of T2 DM combined with NAFLD.2.CysC levels in T2 DM patients have a significant positive correlation with age,SBP,and GGT.3.The lower age group was more severe in patients with T2 DM combined with NAFLD.