The Experience Research Of Reflux Esophagitis Treating By Professor ZHOU Zhongying Based On Data Mining

Objective:To summarize the clinical experience and medication characteristics of Professor Zhou Zhongying in differentiating and treating reflux esophagitis,and to inherit the clinical experience and academic thought of distinguished old Chinese doctors in differentiating and treating the syndrome of spleen and stomach.Methods:Collected from 1997 to 2014,professor Zhou Zhongying make a diagnosis and give treatment of reflux esophagitis,medical record data,screening to get up to the standard of 70 cases of 211 clinical basis as the research object,establish a database,using data mining technology,on the basis of symptoms,tongue veins,pathogenesis and drug therapy,combined with the basis of the results are analyzed and discussed.Results:There were a total of 70 cases,among which 211 medical cases met the inclusion criteria,including 43 males(111 consultations)and 27 females(100 consultations).The ratio of males to females was 1.6:1.The males were significantly higher than females,and their ages were mainly 30-59 years old.In terms of clinical symptoms,the main clinical manifestations of reflux esophagitis were pantopantoic acid(44.55%),gas(39.34%),heartburn(37.91%),dry mouth(28.91%),gastric ruffia(27.49%),epigastric pain(24.64%),etc.In terms of pathogenesis,disharmony between liver and stomach and obstruction of dampness-heat were the main pathogenesis,accounting for 71.56%and 67.77%,respectively.The other pathogenesis,in order of frequency,were:injury of Qi and Yin(11.37%),weak qi stagnation of stomach(10.90%),interconnection between cold and heat(7.58%),and loss of division of blood flow(7.11%),dampness-heat stasis(4.74%),inversion of stomach qi(4.74%),etc.The main disease site syndrome were stomach(99.05%),liver(80.09%)and spleen(74.88%).The disease site syndrome were heat(93.36%),dampness(81.52%),qi stagnation(81.04%),fluid injury(28.91%)and qi deficiency(20.38%).In terms of drugs,12 kinds of drugs were used more than 100 times,including Coptis chinensis(95.73%),Pinellia pinellia(86.73%),dandelion(81.52%),Cornus officinalis(77.73%),Fructus officinalis(76.30%),Patchouli(73.46%),Cuttlebone(72.04%),Magnolia officinalis(64.45%),Tangerine peel(63.98%),Radix Scutellariae(56.40%),bamboo shavings(54.03%)and Fructus aurantii(51.18%).Classified according to drug efficacy,Qi regulating drugs(17.27%),hydrating and dampening drugs(11.62%),heat-clearing drugs(11.38%)and phlegm-reducing drugs(11.10%)were the main anti-pathogenic drugs,while Qi and Yin nourishing drugs(6.38%),Wen Li drugs(5.26%)and Qi and spleen enhancing drugs(1.94%)were the main anti-pathogenic drugs.Conclusion:The basic pathogenesis of reflux esophagitis is reversed flow of Qi and turbidities ascending.The main pathological factors are dampness,heat and stagnation of Qi,and many pathological factors such as fluid injury,Qi deficiency and Qi inversion are often mixed.Lesions in the esophagus,the disease should belong to the stomach,and closely related to the liver,spleen.Specific treatment methods include removing heat and dispersing dampness,dredging liver and discharging heat,replenishing Qi to invigorating the spleen,supplementing qi and nourishing Yin,removing blood stasis and dredging collateral channels,and making acid and stomach.Common prescriptions include Zuojin Pill,Qingzhong Decoction,Xiangsu Decoction,Liansu Decoction,Lianpu Decoction,Banxia Xiexin Decoction,Xiaochengtang,Erchen Decoction,etc.Differentiation and treatment characteristics:review the disease and seek the mechanism of treatment,replicating the method and prescription corresponding to the pathogenesis,like to use anthers and stomach to regulate qi,prescription flexible and variable dosage.