| Objective:To explore the effect of Jianpi Bushen recipe in improving cancer-related fatigue,and the influence on patients’ discomfort symptoms and quality of life.At the same time,to explore the related factors of cancer-induced fatigue.Methods:In this study,50 patients with colorectal cancer admitted to the oncology department of Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from June 2020 to January 2021 were selected.They were randomly divided into experimental group and control group.In our study,50 patients with colorectal cancer admitted to the oncology department of Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from June 2020 to January 2021 were selected.They were randomly divided into the experimental group and the control group.In the experimental group,on the basis of the conventional treatment of tumor patients,the Jianpi Bushen Recipe was added.Before treatment,14 days after treatment and 28 days after treatment,piper scale information of patients,KPS scores before and after treatment,improvement of TCM symptoms and TCM syndrome scores were collected and recorded.Patients’ general personal information and disease-related information should also be recorded before enrollment.Results:A total of 50 patients were enrolled in this study,25 cases in the experimental group and 25 cases in the control group.The results showed that the Jianpi Bushen formula could comprehensively reduce the scores of patients with cancer-related fatigue from the five dimensions of behavior,emotion,perception,cognition and fatigue degree,and compared with the group without taking Chinese medicine,it could improve the discomfort of fatigue from psychological and physiological aspects,and the treatment effect was statistically significant(P<0.05).In the multi-dimensional comparison between the groups,it was found that the effect of traditional Chinese medicine was related to the length of time.The results showed that only in perception group,there was a statistical difference between the two groups at 14 days and 28 days after treatment(P<0.05).Other behavioral,emotional,cognitive,and mean scores were only 28 days after treatment,and the differences between the two groups were statistically significant.In addition,the Jianpi Bushen formula can also improve the patients’ KPS scores and TCM syndrome scores,and both have statistical significance.In the analysis of related factors,there was no statistical significance in gender,age,disease location,surgery,radiotherapy and chemotherapy,targeted therapy,degree of bone marrow suppression,degree of anemia,basic diseases and cancer-related fatigue.However,the emotional and behavioral dimensions of cancer-related fatigue were correlated with the stage.The specific result was that in the behavioral dimension,the behavioral fatigue improvement data of cancer patients with stage Ⅰand Ⅱ showed a statistically significant difference(P<0.05),while there was no statistically significant difference in stage Ⅲ and Ⅳ.In terms of emotion,there were statistical differences between stage Ⅰ data and emotion,perception and cognition,while there were no statistical differences between stage Ⅱ and Ⅲ,Ⅳ,or between Ⅲ and Ⅳ.Again,only stage Ⅰ and stage Ⅱwere found to be statistically significant to each other in terms of perceptual and cognitive and overall scores for cancer-related fatigue.The correlation between residence and behavioral and perception dimensions was statistically significant.Conclusion:Jianpi Bushen formula can effectively improve cancer-related fatigue of patients with colorectal cancer,reduce and improve a variety of discomfort symptoms caused by colorectal cancer itself and during radiotherapy and chemotherapy,improve KPS score,and improve the quality of life.It is also found that the effect of traditional Chinese medicine treatment is related to the treatment time,and the effect may not be obvious in a short time.In addition,no correlation was found between the occurrence of cancer-induced fatigue and gender,age,disease location,surgery,radiotherapy and chemotherapy,targeted therapy,degree of bone marrow suppression,degree of anemia and underlying diseases.Only stage was found to be correlated with the emotional and behavioral dimensions of cancer-induced fatigue.Where you live has an impact on the behavioral and perceptual dimensions. |
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