| Objective:By using ‘Tongfu’ ointment to treat patients with phlegm-heat obturation type community-acquired pneumonia,obsevering the effects of clinical symptoms,inflammation-related indicator and chest CT improvement of the patients,to know the clinical efficacy of using ’Tongfu’ ointment in patients with phlegm-heat type community-acquired pneumonia,so as to provide support for the clinical application of self-made ointment.Methods:This study was designed as a prospective randomized controlled clinical trial.A total of 70 patients with phlegm-heat type community-acquired pneumonia admitted to Zhongshan Hospital of Traditional Chinese Medicine from October 2020 to March 2021 were selected.All the included patients were randomly divided into two groups with 35 patients in each group.Body temperature,time needed for body temperature returned to normal,TCM syndrome score,WBC,CRP,PCT,chest CT indicated inflammation,etc.,were used as observation indexes.Patients in both groups received conventional anti-infection and symptomatic treatment.In the observation group,selfmade ointment was applied externally on the body surface.After 7 days of treatment,the clinical symptoms,TCM syndrome score,WBC,PCT,CRP and other trends of the two groups were compared,as well as the total clinical effective rate of the two groups.To know the safety of the treatment protocol,all abnormal conditions during the treatment were recorded.Statistical analysis was performed using SPSS23.0 software.Results:1.Comparison of general information of patients: there were no statistical differences in age,sex composition and basic diseases(hypertension,diabetes,etc.)between the two groups(p> 0.05).2.Comparison of recover degree of body temperature: there was no statistical difference in body temperature between the two groups at first,(p > 0.05).The distribution of time needed for body temperature returning to normal in 2 groups was the same,and there was no statistical difference(p> 0.05).3.Comparison of white blood cell count level(WBC): the WBC before treatment was comparable between the two groups(p> 0.05).After treatment,the WBC in 2 groups was both significantly different from that before treatment(p< 0.05).There was no significant difference in WBC between the two groups after treatment(p>0.05).4.Comparison of serum C-reactive protein(CRP): the CRP before treatment was comparable between the two groups(p> 0.05).There was statistical difference in CRP between 2 groups before and after treatment(p<0.05).After treatment,there was no significant difference in serum CRP between 2 groups(P> 0.05).5.Comparison of serum procalcitonin(PCT): there was no statistical difference in PCT between the two groups before treatment(p> 0.05).The serum PCT of 2 groups before and after treatment had statistical difference(p< 0.05).After treatment,there was no significant difference in serum PCT between the observation group and the control group(p> 0.05).6.Comparison of TCM symptom scores: Before treatment,the two groups were comparable in TCM symptom scores(p> 0.05),but after treatment,there were no significant differences in TCM symptom scores such as axillary temperature level,sputum characteristics,chest tightness or chest pain symptoms,urine characteristics and pulmonary rale between the two groups(p>0.05).After treatment,scores of cough degree,24 h sputum volume,stool traits,thirst degree and tongue coating traits in 2 groups had statistical significance(p < 0.05).7.Comparison of total scores of TCM symptoms: the total scores of original TCM symptoms in the two groups were comparable(p>0.05).After treatment,the total scores of TCM symptoms in the two groups were statistically significant,and the observation group was better than the control group(p<0.05).There was statistical difference in TCM syndrome scores between the two groups(P<0.05).8.Comparison of clinical efficacy: After 7 days of treatment,there was significant difference in clinical efficacy between the observation group and the control group(p<0.01).After treatment,the data of observation group was better than control group.9.Safety evaluation: No serious adverse reactions were observed in all patients during the treatment process.The clinical study on Tongfu ointment in the treatment of community-acquired pneumonia with phlegm-heat obstructive pulmonary obstruction is safe and reliable.Conclusion:1.On the basis of conventional anti-infection and symptomatic treatment of Western medicine,combined with external application of Tongfut ointment can better improve the clinical total effective rate of patients with phlegm-heat type community-acquired pneumonia.2.Combined application of Tongfu ointment in the treatment of phlegmheat type community-acquired pneumonia can significantly improve cough,reduce phlegm volume,improve stool characteristics and reduce thirst.3.The combined application of Tongfu ointment in the treatment of phlegmheat type community-acquired pneumonia has the same effect as conventional Western medicine treatment in terms of body temperature recovery and improvement of WBC,CRP,PCT and other inflammation-related indexes in patients... |
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