Clinical Study On The Correlation Between Maternal Whole Blood Cell Test And Pre-eclampsia During Pregnancy

Objective:To compare the differences of peripheral blood cell indexes between normal pregnant women and pre-eclampsia pregnant women,and to carry out the correlation clinical analysis.Methods:Healthy pregnant women(665 cases)who delivered in Jiangsu SubeiPeople’s Hospital from January 1,2017 to December 31,2020.were selected as normal control group A and met the diagnostic criteria for pre-eclampsia during the same period.Pregnant women with severe pre-eclampsia(117 cases)were excluded as experimental group B.Group B was divided into early onset pre-eclampsia B1 group(42 cases).Late onset pre-eclampsia B2 group(75 cases),pregnant women meeting the diagnostic criteria of severe pre-eclampsia in the same period were in group C(141 cases),which were divided into early onset severe pre-eclampsia C1 group(74 cases)and late onset severe pre-eclampsia C2 group(67 cases).All enrolled pregnant women were single pregnancies.All subjects were admitted after admission Before treatment,fasting elbow venous blood was extracted in the morning for blood cell analysis and detection,and the results of various indicators in blood cell analysis were collected to calculate the absolute value of neutrophils/lymphocytes Platelet/lymphocyte absolute value and platelet/mean platelet volume,etc.,using SPSS22.0 data analysis software to deal with the collected data,if there is a correlation analysis of each index with pre-eclampsia,and further explore whether can as predictors of pre-eclampsia diagnosis,analysis between groups of different mother son outcome and complications,and explore the indicators and The correlation of symptoms.Results:1.Five groups of pregnant women in age,gestational age,pregnancy,childbirth time,for the first time prenatal weeks of gestation,whether regular prenatal and household,there was no statistically significant difference(P>0.05),the treatment time is B group,group C within the group comparison,early-onset pre-eclampsia women treatment time were longer than late-onset pre-eclampsia pregnant women,The differences were statistically significant(P<0.05).2.There was no statistically significant difference in white protein,glutamate,transaminase,blood fibroanic,and hematuria nitrogen in the three groups of pregnant women(P>0.05).3.Comparative analysis of platelet parameters:Average of mean platelet volume and platelet distribution width in B and C in the two groups were higher than group A pregnant women,two way in B and C in comparison,early-onset pre-eclampsia than late-onset pre-eclampsia value is high,and the more severe pre-eclampsia illness,the higher the value,and the platelet count,platelet/mean platelet volume average decline with pre-eclampsia is seriously ill,The mean value of early onset pre-eclampsia in group B and group C was lower than that of late onset pre-eclampsia.There were statistically significant differences in platelet count,mean platelet volume,platelet distribution width and platelet/mean platelet volume between groups A,B and C and within groups B and C(P<0.05),while there were no statistically significant differences in platelet volume(P>0.05).4.Comparative analysis of inflammatory indicators:The mean values of white blood cell count,neutrophil count and neutrophil/lymphocyte absolute value in group B and C were higher than those in group A,and increased with the aggravation of the severity of pre-eclampsia.When compared in group B and C,early onset pre-eclampsia was higher than late onset pre-eclampsia.The absolute value of platelet/lymphocyte showed A decreasing trend in the comparison between groups A,B and C,and the mean value of early onset pre-eclampsia was lower in the comparison between groups B and C.In A,B,C,B,C in two way between the three way comparison,white blood cell count,neutrophil count,neutrophil/lymphocyte absolute value,platelet/lymphocyte absolute value between the difference had statistical significance(P<0.05),while the number of lymphocytes,monocytes number no statistical difference(P>0.05).5.The comparative analysis of other relevant indicators:red blood cell volume distribution width coefficient of variation of average in B and C in the two groups were higher than group A pregnant woman,and severity with pre-eclampsia is aggravating,comparison,in the B,C two way early-onset pre-eclampsia up from late-onset pre-eclampsia,differences were statistically significant(P<0.05);Other indicators,such as red blood cell count,hemoglobin,standard deviation of red blood cell distribution width and specific red blood cell volume,had no significant statistical differences between groups A,B and C and within groups B and C(P>0.05).6.The AUC value calculated by drawing the ROC curve showed that the average platelet volume was 0.630,the platelet distribution width was 0.575,the platelet/average platelet volume was 0.715,the absolute value of neutrophils/lymphocytes was 0.681,the absolute value of platelet/lymphocytes was 0.64,and the coefficient of variation of RBC volume distribution width was 0.601.The AUC of mean platelet volume,platelet/mean platelet volume,neutrophil/lymphocyte absolute value,platelet/lymphocyte absolute value,RBC volume distribution width variation coefficient were higher than 0.6,which had certain diagnostic value for pre-eclampsia.7.Postpartum hemorrhage was the most common complication among pregnant women in group A,B and C,and the probability of occurrence increased with the aggravation of the disease,but the difference was not statistically significant(P>0.05).Pregnant women in Group A mainly delivered via vagina,while those in Group B and C mainly delivered by cesarean section,and the rate of cesarean section in Group C was higher than that in Group B.There was no statistically significant difference in gender among A,B and C groups(P>0.05),but there was A statistically significant difference in neonatal morbidity(P<0.05).Neonates in group B and group C were mainly low birth weight infants.8.Among the maternal complications,postpartum hemorrhage,placental adhesion,and HELLP syndrome were negatively correlated with the absolute value of platelet/lymphocyte,and placental abruption was positively correlated with platelet distribution width.Myocardial damage was positively correlated with neutrophil count in neonatal complications.Conclusions:1.Mean platelet volume,platelet distribution width,platelet count,platelet/mean platelet volume;WBC count,neutrophil count,neutrophil/lymphocyte absolute value,platelet/lymphocyte absolute value;Red blood cell volume distribution width coefficient of variation in pre-eclampsia in pregnant women and healthy pregnant women are obviously different,in early-onset pre-eclampsia and there are obviously different in the late-onset pre-eclampsia,are statistically significant,said its associated with pre-eclampsia and its severe degree,and with early-onset and late-onset pre-eclampsia.2.Mean platelet volume,platelet/mean platelet volume,absolute value of neutrophils/lymphocytes,absolute value of platelet/lymphocytes,and coefficient of variation of RBC volume distribution width have certain diagnostic significance for the severity of pre-eclampsia,which can be used in the screening and prediction of pre-eclampsia.The absolute value of platelet/lymphocyte,the width of platelet distribution and the number of neutrophils are correlated with the occurrence of maternal and infant complications of pre-eclampsia,which should be paid more attention during pregnancy.However,blood routine is a routine obstetric examination item with low cost,convenient collection means and convenient clinical use.It is highly operable and easy to promote to primary hospitals.