| Objective: To evaluate the severity of the disease by comparing the clinical symptoms and imaging results of different NT-pro BNP level groups,and to investigate other laboratory data of different NT-pro BNP level groups in children with glomerulonephritis after acute streptococcal infection.Research Methods:(1)Clinical data of hospitalized children with acute streptococcal post-streptococcal glomerulonephritis who were discharged from the pediatrics department of Xiangxi People’s Hospital and diagnosed from March 2015 to February 2021 were analyzed.A total of 193 cases were included in the study.(2)Perform general clinical data statistics and classification processing for all cases that meet the inclusion criteria.(3)Then the patients with complete clinical data were divided into the control group(101 cases)and the experimental group(92 cases),respectively,NT-Pro BNP≤4000pg/ml and > 4000pg/ml.Results:(1)general information: 193 cases of children,gender distribution: male accounted for 134 cases,accounting for 69.4%,female 59 cases,accounting for 30.6%;Age distribution: 13 cases of pre-school age children(6.8%),129 cases of school-age children(66.8%),51 cases of adolescent children(26.4%);Urban and rural distribution: 27 cases(13.9%)lived in cities,and 166 cases(86.1%)lived in rural areas.(2)Clinical features and laboratory tests: 146 cases of children had a history of prodromal infection,69 cases(35.8%)had a history of skin infection,65 cases(33.7%)had a history of upper respiratory tract infection,12 cases(6.2%)had both,47 cases(24.3%)had none of them.Among the193 children,all children had microscopic hematuria,181 cases(93.7%)had edema,111 cases(57.5%)of oliguria,51 cases(26.4%)of gross hematuria,and 118 cases of proteinuria(74.1)%)and 143 cases of hypertension(74.1%),which are important clinical features.Among the193 children,all children had a decrease in serum complement C3,42 cases(21.7%)had a decrease in serum complement C4,and 164 cases(85.0%)had an increase in anti-streptococcal "O" hemolysin,162 Cases(83.9%)had rapid erythrocyte sedimentation rate.(3)In the comparison of clinical data and laboratory data between the experimental group and the control group,there is no statistical difference in gender(P=0.359),age(P=0.120),height(P=0.172),and weight(P=0.408)Significantly,the two groups have statistically significant differences in symptoms and examinations of severe circulatory congestion.APSGN without severe circulatory congestion and APSGN with severe circulatory congestion are compared with NT-pro BNP.The cut-off value of blood NT-pro BNP is 4000pg/m L.The sensitivity of this value is 89.2%,the specificity is 82.54%.The two groups were in high blood pressure(P=0.0004),white blood cell count(P<0.001),centrogranule ratio(P<0.001),lymphocyte ratio(P<0.001)β2 microglobulin(P=0.001),cystatin There were statistically significant differences in C(P=0.006),N-acetyl-β-D-glucosidase(P=0.038),and glomerular filtration rate(P=0.03).The two groups had no significant difference in C-reactive protein,creatine kinase isoenzyme(CK-MB),creatine kinase(CK),and lactate dehydrogenase(LDH)on procalcitonin(P>0.05).Research conclusion:1.NT-pro BNP level can effectively assess the severity of APSGN in children.When NT-pro BNP is 4000pg/m L,it indicates that APSGN is more likely to be complicated with severe circulatory congestion.The experimental group(NT-Pro BNP > 4000pg/ml)was more likely to have severe circulatory congestion.An early warning indicator to guide clinicians in early diagnosis of severe circulatory congestion.2.In children with APSGN,the level of NT-Pro BNP is associated with hypertension.3.The level of NT-Pro BNP was used as a potential marker reflecting early renal function injury in children with APSGN. |
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