Prognostic Value Of N-terminal Brain Natriuretic Peptide In ICU Patients With Bloodstream Bacterial Infection

Objective:To investigate the value of serum N-terminal pro brain natriuretic peptide(NT-proBNP)in evaluating the prognosis of patients with bloodstream bacterial infection and to provide reference for clinical treatment.Methods:three general hospitals from June 2014 to June 2016 in ICU(ICU)bacteremia,sepsis,septic patients 240 cases as the research object,according to the 28 day prognosis were divided into survival group and death group,compared two groups of patients with early onset N-terminal pro brain natriuretic peptide(NT-proBNP)and procalcitonin(PCT),high sensitive C reactive protein(HS-CRP),and acute physiology and chronic health evaluation(APACHE II)score correlation,and the receiver operating characteristic curve(ROC)were observed in three NT-proBNP,PCT,HS detection index-CRP reference value for prognosis evaluation and using SPSS20.0 software for statistical analysis.Results: 1 bacteremia and septicemia group infection outcomes: survival group and death group were NT-proBNP,PCT,HS,CRP and APACHE score were statistically significant(P < 0.05);NT-proBNP,PCT,HS,CRP and APACHE II score in predicting ROC curve area of death were 0.781,0.619,0.911 and 0.989 NT-proBNP,the sensitivity,specificity and Youden index were 78.1%,91.4% and 0.695 PCT,the sensitivity,specificity and Youden index were 74.1%,80.1% and 0.542 HS-CRP,the sensitivity,specificity and Youden index were 84.2%,34.3% and 0.185,the APACHE score of sensitivity,specificity and Youden index were 99.1%,85.7% and 0.848.2 sepsis group infection outcomes: survival group and death group were NT-proBNP,PCT,HS,CRP and APACHE score were statistically significant(P < 0.05);NT-proBNP,PCT,HS,CRP and APACHE II score in predicting ROC curve area of death were 0.979,0.654,0.939 and 0.915,NT-proBNP the sensitivity,specificity and Youden index were 90.6%,94.3% and 0.849 PCT,the sensitivity,specificity and Youden index were 95.3%,91.4% and 0.867 hs-CRP,the sensitivity,specificity and Youden index were 97.6%,34.3% and 0.319,the APACHE score of sensitivity,specificity and Youden index were 84.7%,82.9% and 0.676.Conclusion: NT-proBNP and PCT have high prognostic value in patients with bloodstream bacterial infection.Combined with APACHE II score to accurately determine the prognosis of patients,it can reduce the mortality of patients with bloodstream infection.