Research On The Compatibility Law Of Medicinal And Edible Ganwei Chinese Medicines And Their Pairs Based On The Theory Of "Ganwei Having The Effect Of Relaxation"

PurposeThis research is based on the theory of " Ganwei having the effect of relaxation",using data mining methods to explore Ganwei Chinese medicines and their compatibility rules,with a view to further elucidating the medicinal properties of Ganwei Chinese medicines and the theory of compatibility of traditional Chinese medicine with seven emotions.It provides references for the clinical application of " Ganwei having the effect of relaxation" Ganwei Chinese medicines in traditional Chinese medicine in terms of safety and rationality,especially attenuation(Medicinal properties)efficiency enhancement,and provides theoretical basis and new ideas for Chinese medicine scientific research,new drug development,traditional Chinese medicine processing,dietary prescription and promotion,etc.MethodBased on the theory of " Ganwei having the effect of relaxation",Eight Chinese medicines with the same source of medicine and food,including Glycyrrhizae Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle,Honey,Jujube fructus,Rice,Black soybean,Green beans,and Malt Sugar,were selected as the research objects.build database.Using the "Traditional Chinese Medicine Inheritance Computing Platform V3.0" software,using frequency analysis,explore the efficacy,properties,and symptoms of the relevant drug pairs that are compatible with 8 Ganwei medicines;use the association rule Apriori algorithm to mine Commonly used drug pairs,commonly used drug pairs containing toxic drugs;using network topology analysis,analyze the core drug pairs of the main disease syndromes,and summarize their compatibility rules.Result1 Analysis on compatibility regularity of Glycyrrhizae Radix et Rhizoma(Licorice)often used in combination with tonic drugs,heat-clearing drugs,and anti-surface medicine.The four qi(natures)of the compatible drugs are mainly warm,followed by cold and flat;the five flavors are more sweet,bitter,and pungent;they are mostly in the spleen and lung meridian;they are compatible with 50 toxic drugs,with a total frequency of 1748 times.When the confidence level is 1,the support level is greater than or equal to10%,21 groups of commonly used drug pairs are obtained;the support level is greater than or equal to 5%,and 10 groups of commonly used drug pairs are compatible with toxic drugs.Licorice-related drug pairs can be used to treat 530 diseases and syndromes,and it is concluded that the core drugs for the treatment of colds are Licorice-Scutellaria,Licorice-Ginger;the core drugs for treating cough are Licorice-Platycodon,Licorice-Bitter almond;the core drugs for the treatment of asthenia Licorice-Ginseng,Licorice-Angelica;The core medicine for treating Hou Bi is Licorice-Platycodon,Licorice-Mint,and Licorice-Scrophularia.2 Analysis on compatibility regularity of Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle(Honey Roasted Licorice)It is often used in combination with tonic drugs and anti-surface drugs.The four qi(natures)compatibility drugs are mainly warm,followed by cold and flat;the five flavors are more sweet,bitter,and pungent;they are mostly in the spleen and lung meridian;39 kinds of toxic drugs are compatible,with a total frequency of 1336 times.When the confidence level is 1,the support level is greater than or equal to 10%,20 groups of commonly used drug pairs are obtained;the support level is greater than or equal to 5%,and 7 groups of commonly used drug pairs are compatible with toxic drugs.Honey Roasted Licorice herbs can be used to treat 370 kinds of diseases and syndromes,and the core medicines for the treatment of fatigue are Honey Roasted Licorice-Ginseng,Honey Roasted Licorice-Atractylodes,Honey Roasted Licorice-Poria;The core drugs for cold treatment are Honey Roasted Licorice-Ginger,Honey Roasted Licorice-Jujube fructus;the core medicine for treating cough is Honey Roasted Licorice-Bitter almond,Honey Roasted Licorice-Ginger,Honey Roasted Licorice-schisandra,Honey Roasted Licorice-Ginseng;the core medicine for treatment of diarrhea is Honey Roasted Licorice-Ginseng,Honey Roasted Licorice-atractylodes,and Honey Roasted Licorice-Poria.3 Analysis on compatibility regularity of Honey It is often used in combination with tonic medicine and heat-clearing medicine.Compatibility of the four qi drugs is mainly warm,followed by mild and cold;five flavors are more sweet,bitter,and pungent;mostly in the kidney,spleen,and liver channels;compatibility with 49 toxic drugs,with a total frequency of 1464 times.When the confidence level is 1,the support level is greater than or equal to 10%,22 groups of commonly used drug pairs are obtained;the support level is greater than or equal to 5%,and 9 groups of commonly used drug pairs are compatible with toxic drugs.Honey can be used to treat 356 diseases and symptoms.The core medicine for treating fatigue is Honey-Ginseng and Honey-Tuckahoe;the core medicine for treating cough is Honey-Bitter almond;the core medicine for curing constipation is Honey-Hemp seed and Honey Rhubarb,Honey-Bittet Orange;the core medicine for treating abdominal pain is Honey-Ginseng,Honey-Atractylodes,Honey-Dried Ginger.4 Analysis on compatibility regularity of Jujube fructus It is often used in combination with tonic and anti-expression medicine.Compatible drugs: Four Qis are mainly mild;the five flavors are sweet,pungent,and bitter;they are mostly in the spleen and lung meridian;36 toxic drugs are compatible with a total frequency of 243 times.When the confidence level is 1,the support level is greater than or equal to 10%,20 groups of commonly used drug pairs are obtained;the support level is greater than or equal to 5%,and 10 groups of commonly used drug pairs are compatible with toxic drugs.Jujube fructus can be used to treat 280 diseases and syndromes,and the core medicine for treating fatigue is Jujube fructus-Ginger,Jujube fructus-Ginseng,Jujube fructus-Atractylodes;the core medicine for cold treatment is Jujube fructus-Ginger;the core medicine for treating diarrhea The medicine is Jujube fructus-Ginger,Jujube fructus-Poria,Jujube fructusLargehead Atractylodes Rhizomes;the core medicine for treating cough is Jujube fructus-Ginger,Jujube fructus-Ginseng,Jujube fructus-Bitter almond.5 Analysis on compatibility regularity of Rice It is often used in combination with tonic medicine and heat-clearing medicine.The four qi of compatibility drugs are mainly warm,followed by mild and cold;the five flavors are more sweet,bitter,and pungent;mostly return to the spleen,lung,stomach and heart meridian;compatibility with 12 kinds of toxic drugs,the total frequency is 41 times.When the confidence level is 1 and the support level is greater than or equal to 10%,10 groups of commonly used drug pairs are obtained;the support level is greater than or equal to 15%,and 8 groups of commonly used drug pairs compatible with toxic drugs are obtained.Rice can be used to treat 78 diseases and syndromes,and the core medicine for treating fatigue is Rice-Ginseng;the core medicine for treating cough is Rice-Jujube fructus,Rice-Cortex mori radicis;the core medicine for treating diabetes is Rice-Licorice,Rice-Ophiopogon japonicus.6 Analysis on compatibility regularity of Black soybean It is often used in combination with tonic drugs and relieve the surface.Compatibility of the four qi drugs is mainly warm and flat,followed by cold;five flavors are more sweet,bitter,and pungent;mostly in the spleen and liver meridian;compatible with 21 kinds of toxic drugs,with a total frequency of 73 times.When the confidence level is 1 and the support level is greater than or equal to 10%,15 groups of commonly used drug pairs are obtained;the support level is greater than or equal to 10%,and 7 groups of commonly used drug pairs compatible with toxic drugs are obtained.Black soybeans can be used for the treatment of 66 diseases and syndromes.The core medicine for treating dysentery is Black soybean-poppy shell,Black soybean-Honey Roasted Licorice,Black soybean-Dried Ginger;the core medicine for treating edema is Black soybean-Atractylodes,Black soybean-Poria,Black Soybean-Mulberry bark;The core medicine for the treatment of poisoning is Black soybean-Licorice.7 Analysis on compatibility regularity of Green beans It is often used with heat-clearing medicine,tonic medicine and anti-surface medicine.The four qi of compatibility drugs are mainly cold and warm,followed by flatness;five flavors are more sweet,bitter,and pungent;mostly in the stomach,heart,and lung meridians;compatibility with 15 toxic drugs,with a total frequency of 41 times.When the confidence level is 1,the support level is greater than or equal to 10%,10 groups of commonly used drug pairs are obtained;the support level is greater than or equal to 15%,and 5 groups of commonly used drug pairs compatible with toxic drugs are obtained.Green beans can be used to treat 48 diseases and syndromes.The core medicine for acne treatment is Green beans-Saponins;the core medicine for treatment of poisoning is Green beans-Licorice.8 Analysis on compatibility regularity of Malt Sugar Compatible medicines are used as tonic drugs,anti-epidemic drugs,phlegm-relieving cough and asthma-relieving drugs.Compatibility of the four qi drugs is mainly warm,followed by cold and flat;the five flavors are more sweet,bitter,and pungent;they are mostly in the spleen and lung meridian;they are compatible with 6 toxic drugs,with a total frequency of 14 times.When the confidence level is 1,the support level is greater than or equal to 15%,18 groups of commonly used drug pairs are obtained;the support level is greater than or equal to 50%,and 2 groups of commonly used drug pairs compatible with toxic drugs are obtained.Malt Sugar can be used to treat 23 diseases and symptoms.The core medicines for treating fatigue are Malt Sugar-white peony,Malt Sugar-Jujube fructus,Malt Sugar-Ginger;Malt Sugar-Honey,Malt Sugar-Bitter almonds are the core medicine for treating cough.ConclusionBased on the statistics of data mining data of medicine pairs composed of Ganwei medicines with the same medicine and food,it is concluded that most of the compatible medicines are tonic;the four qi(nature)are mainly warm and flat;the five tastes are mostly sweet.,Pungent,bitter taste;more channels return to the spleen and lung channels;it can be used with 50 toxic drugs.Based on the analysis of the above results,the above-mentioned eight Ganwei medicines have the theory of " Ganwei having the effect of relaxation",which covers through and drug toxicity,alleviation of cold/heat/dryness of the drug,alleviation of the potency of severe drugs,alleviation of unpleasant odors of drugs,and synergistic effect of the same taste.And so on,in order to achieve the purpose of reducing toxicity(reducing intensity)and increasing efficiency.The composition of the " Ganwei having the effect of relaxation" drug pair has the effects of relieving pain,relieving toxicity,relieving the middle and nourishing deficiency,replenishing qi and relieving cough,and can be used clinically to treat a variety of related diseases.This research has theoretical value and practical guiding significance for clinical Chinese medicine,scientific research and development.