Research On The Relationship Between Serum PG And G-17 Levels In Patients With Chronic Atrophic Gastritis

Objective:In this study,syndrome element theory was applied to extract syndrome element characteristics of patients with chronic atrophic gastritis with different serum PG and G-17 levels.It can clarify the distribution of syndromes,analyze their correlation and clinical significance.This study aims to provide new TCM clinical diagnosis and treatment ideas for CAG patients with different serum PG and G-17.Methods:A total of 100 patients with chronic atrophic gastritis and clinical symptoms who were admitted to the outpatient and inpatient departments of our hospital from February 2020 to February 2021 and met the diagnostic criteria for chronic atrophic gastritis with the results of electronic gastroscopy combined with pathological examination were collected according to the intake and discharge criteria.Serum PG Ⅰ,PG Ⅱ and Gastrin G-17 were detected by ELISA,and the ratio of PG Ⅰ / Ⅱ(PGR)was calculated.According to the normal or not of serum indexes,50 patients were divided into normal group and abnormal group,respectively.Through the form of questionnaire survey,collect the symptoms and signs of patients and other four diagnostic information.The information of the four diagnoses was input into the "TCM health status identification and consultation system",and the corresponding syndrome elements and scores were obtained.Finally,SPSS 25.0 was used to establish a database for statistical analysis,and the distribution of CAG syndrome elements under different serum PG and G-17 levels and their correlation were analyzed.Results:1.General information: In this study,there were no statistical differences in gender and age distribution between the normal serum indexes group and the abnormal serum indexes group(P>0.05).But on the whole,the distribution of age groups in the middle and old accounted for a high proportion.2.The distribution of related indexes:(1)In the group with abnormal serum indexes,there were 21 cases(42.00%)whose PG Ⅰ was lower than the reference range.PG Ⅱ was higher than the reference range in 16 cases,accounting for 32.00%.PGR was below the reference range in 14 cases(28.00%).G-17 was above the reference range in 13 cases,accounting for 26.00%.G-17 was below the reference range in only 7 cases,accounting for14.00%.(2)In terms of Hp infection,11 cases(22.00%)were Hp positive and 39 cases(78.00%)were Hp negative in the normal serum index group.In the group with abnormal serum indexes,15 cases(30.00%)were Hp positive,and 35 cases(70.00%)were Hp negative.According to the statistics,there was no statistical significance in Hp infection rate between the two groups(P>0.05).3.The characteristics and distribution of syndromes in normal serum indexes:(1)The main syndromes were in stomach,spleen,liver,gallbladder,kidney and small intestine.(2)The main syndrome of solid disease is qi stagnation.The main deficiency syndrome element is Yin deficiency.4.The characteristics and distribution of syndromes with abnormal serum indexes:(1)The main syndromes were in stomach,spleen,liver,kidney,small intestine and gallbladder.(2)The main syndrome of solid disease is dampness.The main deficiency syndrome element is qi deficiency.5.Comparison of syndrome elements in each group: there were differences in the grade distribution of stomach,spleen,liver,heat,Yang deficiency,qi deficiency,blood stasis,blood deficiency and cold syndrome elements between the normal serum index group and the abnormal serum index group(P<0.05),and there were strong correlations between qi deficiency,blood stasis and cold and the abnormal serum index group(P<0.05,OR>3).Conclusion:1.The serum PG and G-17 levels of CAG patients were correlated with the overall syndrome element levels.2.The normal level of CAG with serum PG and G-17 mainly involves the dysfunction of the stomach,spleen,liver,gallbladder,kidney and small intestine.The pathological factors were the inclusion of void and solid,mainly Qi stagnation,dampness and phlegm.3.Abnormal levels of serum PG and G-17 with CAG mainly involve dysfunction of the stomach,spleen,liver,kidney,small intestine and gallbladder.The main pathological factors were dampness,qi stagnation and qi deficiency.4.Studies show that traditional Chinese medicine treatment of CAG patients should focus on clearing damp to dissipate phlegm,invigorate spleen and stomach,smooth liver and regulate qi.For CAG patients with abnormal serum PG and G-17,qi and kidney should be invigorated,blood circulation to remove blood stasis,cold and colladals-clearing should be eliminated.