| Objective: In this study,we sought to evaluate the association between fibrinogen-toalbumin ratio(FAR)and hs-CRP to the degree and severity of coronary artery disease evaluated by Gensini Score(GS)and examine whether the FAR combined with hs-CRP were able to predict the in-hospital prognosis of patients with AMI.Methods: The trials made use of the information of 240 patients from Jun.2018 to Dec.2019 who went to Cardiology of Gansu Provincial Hospital and underwent primary coronary angiography(CAG).Accordingly,the patients were subdivided into normal control group(n=52)and AMI group(n=188);The AMI group was subdivided into 91 cases from the group with lower Gensini score(GS≤58)and 97 cases from the group with higher Gensini score(GS>58);The AMI group was subdivided into major adverse cardiovascular events(MACE)with 31 cases and non-MACE with 157 cases according to the occurrence of MACE in the hospital.Compared with the general data,laboratory and interventional treatment related data between the control and the AMI,the AMI lesion subgroups,the non-MACE and the MACE,and person or spearman correlation analysis methods are used to study the correlation between fibrinogen(FIB),albumin(ALB),hs-CRP,FAR and Gensini score in AMI patients.Using logistic regression to analyze autocephalous MACE risk factors in AMI patients.The receiver operating curve(ROC)determines the forecast value of FAR,hs-CRP,and FAR together with hs-CRP for in-hospital MACE in AMI patients.Results: 1.Comparison of baseline data between the control group and the AMI group:Compared with the control group,the proportion of men in the AMI group,age,proportion of diabetes,FIB,NT-Pro BNP,WBC,NEUT,ALT,hs-CRP,FAR,etc.were higher,while ALB,TG,HDL-C,RBC,LVEF,etc.were low,with statistical differences(P<0.05).2.Comparison of FIB,ALB,hs-CRP,FAR in each subgroup of AMI: FIB,hs-CRP and FAR of the low Gensini score group and high Gensini score group were higher than those of control group,whereas ALB were inferior to those of control group(P<0.05);the lower Gensini score group FIB,hs-CRP,FAR were inferior to the higher Gensini score group,while ALB was higher than the higher Gensini score group(P<0.05).3.Gensini score was positively correlated with FIB(r=0.512,P<0.001),hs-CRP(r=0.448,P<0.001),FAR(r=0.586,P<0.001),and negative correlation was detected between ALB and Gensini score(r =-0.398,P<0.001).4.Baseline data of MACE and non-MACE group: Compared with the non-MACE group,the MACE group had higher Diabetes,KILLIP≥ Grade Ⅱ,FAR,FIB,WBC,hs-CRP,Gensini scores,While systolic blood pressure,and ALB,HDL-C and LVEF are low,with statistical difference(P<0.05).5.Logistic regression analysis indicated: diabetes(OR=1.061,95%CI:1.003-1.135),LVEF(OR=0.952,95%CI:0.886-0.993),FAR(OR=1.365,95%CI:1.245-1.481)and hs-CRP(OR=1.148,95%CI:1.099-1.210)were autocephalous hazard for in-hospital MACE in AMI patients(P<0.05).6.The area under the ROC curve(AUC)of FAR combined with hs-CRP for the MACE during hospitalization of AMI patients was 0.724(sensitivity of 74.96%,specificity of 70.44%;95%CI:0.632-0.815,P =0.003).The cutoff value of FAR for the MACE during hospitalization of AMI patients was 82.12(area under the ROC curve: 0.712,sensitivity of 68.91%,specificity of 75.89%;95% CI:0.617-0.808,P<0.001);The cutoff value of hs-CRP for the MACE during hospitalization of AMI patients was 28.60(area under the ROC curve: 0.663,sensitivity of65.22%,specificity of 72.97%;95% CI:0.566-0.757,P<0.001).Conclusion: FAR and hs-CRP were positively relevant to the degree and severity of coronary artery disease evaluated by Gensini Score(GS)in AMI.FAR combined with hs-CRP has better predictive value for the in-hospital prognosis of AMI than single inflammatory indicators such as FAR and hs-CRP.FAR combined with hs-CRP can be used as a biomarker for early assessment of coronary artery disease and in-hospital prognosis in patients with AMI,and has positive significance for early active intervention and reducing the incidence of MACE. |
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