Correlation Between The Ratio Of Fibrinogen To Albumin And The Severity Of Coronary Artery Disease In Elderly Patients With Angina Pectoris

Objective:In this study,the elderly patients with angina pectoris were taken as the research object,and the coronary Gensini(GS)score was used as the grouping standard to analyze the correlation between the ratio of fibrinogen to albumin(FAR)and the severity of coronary artery disease in elderly patients with angina pectoris and its predictive value.Methods:From January 2022 to December 2022,186 patients with angina pectoris who were hospitalized in the Cardiovascular Department of People ’s Hospital Of Liaoning Province and underwent Coronary angiography,CAG)were selected according to the selection criteria and exclusion criteria.Coronary angiography and related biochemical and physical examinations were completed in all patients.Collect relevant data of all included patients,and include gender,age,smoking history,drinking history,hypertension history,diabetes history,etc.into the baseline data;Platelet(PLT),neutrophils(NEUT),alanine aminotransferase(ALT),albumin(ALB),creatinine(Cr),fibrinogen(FIB),total cholesterol(TC),low density lipoprotein(LDL),high density lipoprotein(HDL)Biochemical indexes such as fasting blood glucose(GLU)and physical indexes such as ejection fraction(EF)and coronary angiography data were included in the clinical data.Register the above information item by item.The FAR value is sorted according to the calculation formula FAR=FIB(g/d)/ALB(g/l)*100,and the GS integral results are summarized according to the GS integral standard.According to the GS score,the enrolled patients were divided into non-severe group(Gensini≤60,n=139)and severe group(Gensini>60,n=49).SPSS 25.0 statistical software is used.Adopt independent sample t-test for the measurement data conforming to normal distribution;The measurement data that do not conform to the normal distribution shall use the rank sum test,and the counting data shall use the chi-square test.Compare whether the general data of non-severe group and severe group are statistically significant.The variables with statistical differences in univariate analysis were included in multivariate Logistic regression analysis to analyze the relationship between these variables and severe coronary artery disease.Spearman correlation analysis was performed between the variables with statistical differences in univariate analysis and the coronary GS score to analyze the correlation between these variables and the degree of coronary disease.The ROC curve was drawn to evaluate the predictive value of FAR for severe coronary artery disease.Result:1.Comparison of baseline data between non-severe group and severe group.History of diabetes [37(20%)vs.25(37.3%),P=0.002] There was significant difference between the non-severe group and the severe group(P<0.05).However,there was no significant difference in gender,age,smoking history,drinking history and hypertension history between the non-severe group and the severe group(p >0.05).2.Comparison of clinical data between non-severe group and severe group.HDL,FIB,ALB,Cr,FAR and EF values were significantly different between the non-severe group and the severe group(P<0.05).However,WBC,NEUT,HB,PLT,D-D,LDL,TC,TG,ALT,GLU were not statistically different between the non-severe group and the severe group(P>0.05).3.Multi-factor logistic regression analysis.FAR(OR=1.491,95%CI:1.245-1.787,P=0.000)was a risk factor for the occurrence of severe coronary artery disease in elderly patients with angina pectoris,HDL(OR=0.117,95% CI:0.018-0.760,P=0.025),EF value(OR=0.887,95% CI:0.832-0.946,P=0.000)are protective factors for severe coronary artery disease in elderly patients with angina pectoris.4.Spearman correlation analysis.FIB,Cr,FAR were positively correlated with GS scores of elderly patients with angina pectoris(r=0.389,P=0.000;r=0.266,P=0.000;r=0.469,P=0.000),and the history of diabetes,HDL,ALB,and EF values were negatively correlated with GS scores of elderly patients with angina pectoris(r=-0.224,P=0.002;r=-0.253,P=0.000;r=-0.464,P=0.000 0;r=-325,P=0.000).5.ROC curve analysis and scatter diagram.The working characteristic curve of subjects with FAR and coronary GS score was drawn,and the area under the curve was 0.807(95% Cl:0.745-0.896).The best cut-off point of FAR is 7.03,and its diagnostic efficiency is the highest(sensitivity: 87.8%;specificity: 63.5%).conclusion 1.FAR is a risk factor for serious coronary artery disease in elderly patients with angina pectoris,and HDL and EF values are protective factors for serious coronary artery disease in elderly patients with angina pectoris.2.2.FAR is positively correlated with the severity of coronary artery disease in elderly patients with angina pectoris.3.FAR is helpful to evaluate the severity of coronary artery disease.When FAR is 7.03,its predictive value is the highest,with sensitivity and specificity of 87.8% and 63.5% respectively.