Correlation Analysis Of Clinical Characteristics,bonemetabolism Index,Bone Density And Fracture In Male Patients With Abnormal Bone Mass

Objective: To investigate the clinical characteristics,bone metabolism index,bone density and fracture of male patients with abnormal bone mass.Methods:(1)A retrospective analysis was made of the clinical characteristics,bone metabolism indicators,combined diseases,fractures and other conditions of male patients with abnormal bone mass newly diagnosed in the osteoporosis clinic of a hospital in Shanghai from 2005 to2015.(2)To analyze the correlation between bone metabolism index,bone mineral density and fracture in 928 male patients with abnormal bone mass with different diseases who visited the hospital from 2006 to 2017.Results:(1)The onset age of male patients with abnormal bone mass was mainly distributed in 70～79 years old.Brittle fracture mainly occurred in vertebral body.Among male patients with abnormal bone mass,patients with glucocorticoid use and diabetes accounted for the largest proportion.Through age stratification analysis,the serum levels of osteocalcin(OC)and C-terminal crosslinking tide of type I Collagen(β-CTX)in male patients with abnormal bone mass were gradually decreased with increasing age,and the values were the lowest in the 70-79 year group.The bone density of femur and total hip decreased gradually with the increase of age,and there were statistically significant differences in the bone density of femoral neck compared with the group less than 50 years old,70-79 years old and ≥80 years old(P<0.01).Total hip bone density was statistically significant in the ≥80 age group compared with those younger than 50 years and 50 to 59 years(P<0.05).While Lumbar1-4(L1-4,L1-4)bone density increases step by step with the increase of age,and peaks at70-80 years old and then declines.The ratios between Lumbar 1-4 and 50-59 years old,70-79 years old and ≥80 years old are statistically different(P<0.05).(2)Univariate regression analysis in male patients with abnormal bone mass indicated that age,weight,L1-4 bone density,femoral neck bone density,total hip bone density,β-CTX,chronic stomach disease,and osteoporosis were the influencing factors of fracture history,and the differences were statistically significant(P<0.05).Multi-factor regression analysis showed that age,bone alkaline phosphatase,diabetes and osteoporosis were risk factors for fracture in male patients with abnormal bone mass,and 25 hydroxyvitamin D3 was a protective factor for fracture.Conclusions :(1)The incidence of abnormal bone mass in male patients may be related to aging.The incidence of abnormal bone mass in male patients after 70 years old is significantly higher,and the peak of abnormal bone mass is between 70 and 80 years old.Male brittle fracture occurs in the vertebral body;Long-term use of glucocorticoids and patients with diabetes can easily lead to abnormal bone mass in men,so intervention should be done as soon as possible.(2)To prevent and control the occurrence of fractures in male patients with abnormal bone mass,it is necessary to focus on those patients with older age,higher levels of β-CTX and BALP,combined with chronic stomach disease and type 2 diabetes,and actively intervene and treat osteoporosis to reduce the occurrence of fractures in such patients.