| Objective:To investigate the neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLT)in overweight or obese people,Objective to investigate the correlation between coronary heart disease(CHD)and PLR,uric acid to creatinine ratio,and to further study the correlation between the above three indicators and the degree of coronary artery stenosis,in order to find simple and easily available monitoring indicators for early detection of CHD,and timely prevention or treatment.Methods:(1)From March 2019 to March2020,To collect the basic information and clinical indicators of the non emaciated people who visited the Department of Cardiology of a hospital in Guilin and underwent coronary angiography for the first time.The former includes gender,age,height,weight,blood pressure,past medical history(including hypertension,diabetes,coronary intervention,etc.),while the latter includes neutrophil count,platelet count,lymphocyte count,uric acid,blood pressure,blood pressure,etc.Creatinine and coronary artery disease were measured.Finally,799 patients met the inclusion and exclusion criteria,including 475 males and 324 females.In addition,468 patients were diagnosed with coronary heart disease,accounting for 58.57% of the total subjects.(2)The subjects were divided into four groups: group A(non coronary heart disease group),group B(normal weight coronary heart disease group),group C(overweight coronary heart disease group)and group D(obese coronary heart disease group).The correlation between NLR,PLR,uric acid creatinine ratio and coronary heart disease was analyzed.The relationship between the above indexes and the degree of coronary artery stenosis in overweight or obese patients with coronary heart disease was analyzed,and the risk factors of overweight or obese patients with coronary heart disease were further analyzed.(3)SPSS 23.0 statistical software was used to analyze and process the collected data.Mean ± standard deviation was used to represent measurement data,one-way ANOVA was used to compare between groups,chi square test was used to compare rates,Pearson correlation analysis and linear regression analysis were used to analyze the correlation between variables.Set P < 0.05 as the difference was statistically significant.Results:(1)There were differences in age,systolic blood pressure,prevalence of diabetes,prevalence of hypertension,male ratio,uric acid / creatinine,NLR,PLR,LDL and HDL between CHD group and non CHD group.Except HDL level,CHD group was lower than non CHD group,other indicators with differences were higher than non CHD group,and the differences were statistically significant(P < 0.05)05);(2)The levels of uric acid / creatinine and NLR were compared among the three groups.The results showed that the levels of uric acid / creatinine and NLR in group D(obese coronary heart disease group)were higher than those in group C(overweight coronary heart disease group)and group B(normal weight coronary heart disease group),and the differences were statistically significant(all P <0.05).Compared the PLR levels among the three groups,the difference was statistically significant(P < 0.05),and group C was higher than group B;(3)For overweight and obese patients with coronary heart disease,Gensini score was positively correlated with total cholesterol,LDL,NLR(r = 0.224,0.290,0.238,P < 0.001);(4)age,uric acid / creatinine,NLR,diabetes,male were the risk factors of overweight and obese patients with coronary heart disease Factors(P< 0.01).Conclusion:(1)NLR,PLR and uric acid / creatinine ratio are related to the pathogenesis of coronary heart disease.(2)Overweight and obesity patients with coronary heart disease have higher levels of NLR,PLR,uric acid /creatinine ratio;(3)NLR is related to the degree of coronary artery stenosis in overweight and obesity patients,and is also a risk factor of coronary heart disease in overweight and obesity patients and has certain diagnostic value for coronary heart disease. |
PDF Full Text Request