Application Of Accurate Quantitative SPECT/CT In The Diagnosis And Treatment Of Bone Metastasis Of Prostate Cancer

Purpose:1.Analyze the diagnostic efficacy of conventional bone imaging and quantitative SPECT/CT imaging,and discuss the advantages of quantitative SPECT/CT in the diagnosis of prostate cancer bone metastases.2.According to the results of quantitative SPECT/CT before and after treatment of prostate cancer patients with bone metastases,the SUVmax values of the two bone metastases were compared,and the application of quantitative SPECT/CT in the treatment of bone metastases was evaluated.Methods:1.From August 2018 to January 2020,58 cases in the Department of Nuclear Medicine who underwent whole-body bone imaging and quantitative SPECT/CT bone imaging for prostate cancer were selected.Perform SPECT/CT fusion imaging on suspected patients with abnormal radioactive focus on whole-body bone imaging.Physicians with associate senior titles and above in our department will diagnose the images,follow up the preliminary diagnosis closely,and dynamically monitor imaging changes or Histopathological results confirm the diagnosis.Compare the two diagnosis results,and calculate and analyze the sensitivity,specificity,positive prediction rate,and negative prediction rate of whole body bone imaging and quantitative SPECT/CT imaging for the diagnosis of bone metastasis.SPSS 20.0 software is used to compare whole body bone imaging and Quantitative SPECT/CT imaging diagnosis result data were subjected toχ~2 test.2.Collect 28 cases of diagnosed prostate cancer patients with bone metastases,and perform quantitative SPECT/CT imaging before and after treatment of bone metastases and measure the SUVmax value of their bone metastases.The SPSS 20.0 statistical software was used to perform paired t test on the difference of SUVmax before and after treatment of bone metastases.Results:1.A total of 39 cases of bone metastasis occurred in 58 cases of prostate cancer.Whole body bone imaging diagnosed 46 patients with bone metastases and 12 patients without bone metastases.The sensitivity was 69.5%,the specificity was 41.6%,the positive prediction rate was 82.0%,and the negative prediction rate was 26.3%;SPECT/CT tomographic fusion showed There were 42 patients with bone metastases diagnosed and16 patients without bone metastases.The sensitivity was 85.7%,the specificity was 81.2%,the positive predictive rate was 92.3%,and the negative predictive rate was68.4%.2.Include 25 patients with prostate cancer bone metastasis,collect their SUVmax values before and after treatment of bone metastases,and finally obtain the average SUVmax of bone metastases before treatment of 42.65,and the average of SUVmax after treatment of 36.49,t=4.63,P<0.05,the difference is statistically significant.Conclusion:The accuracy of quantitative SPECT/CT in the diagnosis of bone metastasis of prostate cancer is higher than that of whole body bone imaging,and it has a significant advantage in evaluating the efficacy of bone metastases.