Increased Serum Levels Of C1q/TNF-related Protein-7(CTRP7) Are Closely Associated With Coronary Heart Disease

Objective:Complement Clq tumor necrosis factor related proteins(CTRP)is a protein family.CTRP superfamily includes CTRP7,but there are few studies on its correlation with coronary artery disease(CAD).This study was to investigate the relationship between serum CTRP7 and CAD.Methods:The study subjects were 123 inpatients in our hospital.At the same time,these inpatients received coronary angiography from 2018 to 2019.Among them,96 inpatients were confirmed as coronary heart disease.Meanwhile,27 cases of CAD were ruled out.Baseline datas such as height and weight were collected.Serum levels,such as Urea,Crea,and so on,were tested in our hospital laboratory.We used ELISA to test CTRP7 level.Results:We found that levels of CTRP7 were markedly elevated in CHD patients.To further test whether CTPR7 levels had a link with severity of CAD,we compared CTRP7 levels in different subgroups.As a result,CTRP7 levels in ACS group and severe coronary artery stenosis group were increased.CTRP7 levels were positively correlated with CHOL,TG,LDL(r=0.226 0.208 0.211,P<0.05).In order to test our experiment,we adopted binary Logistic regression analysis.We found CTRP7 was a risk factor for CHD(P<0.05).Conclusion:Elevated levels of CTRP7 were closely associated with coronary heart disease,suggesting that CTRP7 levels may be a risk predictor of CHD.