Clinical Observation On The Treatment Of Mild To Moderate Dry Eye With Diquafosol Sodium Eye Drops

Background:With the aging of the population intensified,environmental pollution problems aggravated and the time of using electronic screen terminals prolonged,the incidence of dry eye in the population is increasing year by year.Patients with dry eye have been suffering from symptoms such as dry eyes,itchy eyes,and fluctuations in vision for a long time,which cause great distress to the daily life of the patients.Dry eye is a chronic disease.Although there are many treatment options available in clinical practice,most of them focus on improving symptoms,and the curative effect is not guaranteed.Diquafosol sodium is a tear secretion promoter,which has been approved for the clinical treatment of dry eye in my country in recent years,but its clinical efficacy and safety for dry eye patients need to be further confirmed.Objective:To observe the effectiveness and safety of diquafosol sodium eye drops in the treatment of mild to moderate dry eye.Methods:A randomized,controlled prospective study.Selected patients with mild to moderate dry eye who received treatment in the Eye Center of Taihe Hospital affiliated to Hubei Medical College from July 2020 to December 2020 as the research subjects.According to the inclusion and exclusion criteria,102 patients(102 eyes)with mild to moderate dry eye were included,they were randomly divided into a test group and a control group.The test group used 3% diquafosol(DQS)sodium eye drops,6times a day,1 drop each time;the control group used 0.1% sodium hyaluronate(SH)eye drops,6 times a day,1 drop each time;Before receiving treatment,7 days after treatment,14 days after treatment,and 28 days after treatment,collect patient-related data(uncorrected visual acuity,bulbar conjunctival hyperemia score,OSDI score,BUT,Schirmer I,FLCS),by comparing the improvement of various indicators between the two groups to evaluate the clinical efficacy of diquafosol sodium eye drops.Statistical data is analyzed by SPSS22.0 software.Results:1.Before treatment,there was no statistical difference between the two groups of patients in terms of age,gender,uncorrected visual acuity,bulbar conjunctival hyperemia score,OSDI,tear film break up time,Schirmer I,corneal fluorescein sodium staining score,.2.The uncorrected visual acuity of patients in the DQS group and SH group was improved at each time node after treatment compared with before treatment,there was a statistical difference in uncorrected visual acuity changes before and after treatment;and there was no statistical difference between the two groups;3.In DQS group,the degree of conjunctival congestion was improved at each time node after treatment,and the difference was statistically significant;In SH group,the improvement of conjunctival hyperemia was not significant after 7 days of treatment;After 14 days and 28 days of treatment,the degree of conjunctival congestion was significantly improved;The improvement of DQS group was more obvious than that of SH group at each time nodes;4.OSDI in DQS group and SH group significantly decreased after 7,14 and 28 days of treatment,and the difference was statistically significant.The decrease in DQS group was more obvious than that in SH group,and the difference was statistically significant;5.In DQS group,the tear film break up time at each time point after treatment was significantly higher than that before treatment,and the difference was statistically significant;In SH group,but was prolonged after 7 days and 14 days of treatment,but the difference was not statistically significant compared with that before treatment.But was prolonged after 28 days of treatment compared with that before treatment;The difference of break up time between the two groups was statistically significant;6.In DQS group,Schirmer I was significantly improved at each time point after treatment,and the difference was statistically significant;In SH group,Schirmer I was improved at each time point,but the difference was not statistically significant;The difference between the two groups was statistically significant.7.The corneal fluorescence staining scores of patients in the DQS group and the SH group were significantly lower at each time node after treatment than before the treatment,and the difference was statistically significant;the difference between the groups was not significant,and there was no statistical significance;8.Adverse reactions in the DQS group occurred The rate was 7.84%,and the SH group was 3.92%.The difference between the two groups was statistically significant.Conclusion:1.Diquafosol sodium eye drops are better than sodium hyaluronate eye drops in improving patient symptoms(OSDI score),reducing ocular surface inflammation(bulbar conjunctival hyperemia score),improving tear film stability(BUT),and promoting tear secretion(Schirmer I).2.Diquafosol sodium eye drops are equivalent to sodium hyaluronate eye drops in improving patients’ UCVA and FLCS.3.The incidence of adverse reactions of diquafosol sodium eye drops is higher than that of sodium hyaluronate eye drops,but the overall safety is still good.