| Purpose: By summarizing and analyzing the clinical data of VBD patients,this study aims to improve people’s cognition of VBD and find secondary preventive measures to prevent the occurrence of clinical symptoms of VBD.To explore the clinical characteristics of VBD cerebral infarction and the risk factors of acute cerebral infarction(ACI)caused by VBD,and to provide ideas for clinical diagnosis and treatment.Methods: A total of 89 patients diagnosed with VBD by cranial CT,CTA,MRI or MRA in the First Hospital of Lanzhou University from September 2018 to September2020 were selected as the case group.Patients in the case group were divided into symptom groups according to their clinical manifestations.50 cases(43 cases of VBD combine with cerebral infarction)and 39 cases in the asymptomatic group.According to imaging data,basilar artery diameter,bifurcation height and deviation of patients in the case group were counted,and differences in baseline data and imaging between the symptomatic group and the asymptomatic group were analyzed.A total of 219 cerebral infarction patients with non-VBD factors were randomly selected as the control group.The degree of neurological impairment and prognosis of patients with cerebral infarction were evaluated according to NIHSS score and MRS score,and there were statistical differences in baseline level,severity of disease and prognosis between patients with cerebral infarction combined with VBD and patients with cerebral infarction without VBD.Results: 1.The diastolic blood pressure and systolic blood pressure of the symptom group were higher than that of the non-symptomatic group,which was statistically significant(P<0.05).There were no statistically significant differences between the two groups in smoking,drinking,past history and blood routine,and biochemical indicators(P>0.05).2.The non-parametric test indicated that the diameter of the basilar artery in the symptom group was larger than that in the non-symptomatic group,and the difference was statistically significant(P<0.05).However,there was no statistically significant difference in deviation and bifurcation height between the two groups.3.The incidence of previous history of hypertension in the VBD cerebral infarction group was significantly higher than that in the non-VBD cerebral infarction group(χ~2 = 88.30,P<0.001).The levels of platelet and uric acid in the VBD cerebral infarction group were higher than those in the non-VBD cerebral infarction group,and the levels of high-density lipoprotein in the VBD cerebral infarction group were lower than those in the non-VBD cerebral infarction group.4.Compared with the non-VBD infarct group,the infarct sites were more common in the posterior circulation,and there was a significant statistical difference(χ~2=17.703,P<0.001).5.Binary Logistic regression analysis was performed on the risk factors of patients in the VBD cerebral infarction group.The results showed: history of hypertension(OR=6.797,95%CI=1.975-3.432,P=0.002),uric acid(OR=1.006,95%CI=0.023-0.162,P=0.007)is a risk factor for VBD cerebral infarction.6.The NIHSS score,MRS1 score and MRS2 score at admission and three months after discharge in the VBD infarction group were higher than those in the non-VBD infarction group,and the difference was statistically significant(P< 0.05).Conclusion: 1.The majority of VBD patients are male,most of whom have a history of hypertension,and the most common clinical manifestation is cerebral infarction.2.Strict blood pressure monitoring in VBD patients may reduce the occurrence of clinical symptoms in VBD patients.3.Hyperuricemia and history of hypertension are independent risk factors for cerebral infarction in VBD group.4.The infarct site of patients with cerebral infarction in the VBD group was more common in the posterior circulation,and their condition on admission was more serious than that in the non-VBD group,with poor prognosis. |
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