The Association Between Short-term Clinical Outcome Of Acute Cerebral Infarction Patients And Serum Uric Acid As Well As Other Relevant Factors

[Objective]We analyzed the relationship between serum uric acid (SUA) as well as other relevantfactors and the prognosis at discharge among patients with acute cerebral infarction,to providescientific evidence for the effective treatment, rehabilitation and management for the acutestroke patients.[Methods]In564cases of acute cerebral infarction patients,we collected demographic characteristic,lifestyle, medical history, admission blood pressure, laboratory test results and recovery ofneurological function at discharge. The clinical prognosis of patients with acute cerebralinfarction as determined by the modified Rankin Scale score (mRs score) at discharge,poorclinic outcome was defined as mRs≥3. Using non-conditional multivariate logistic regressionmodeling, we explored the relationship between SUA levels as well as other relevant factorsand patient’s short clinical prognosis. we analysis the association between serum uric acid andthe poor outcome and calculate the odds ratio and95%confidence intervals.[Results]1. The age of patient, history of atrial fibrillation, previous stroke history, systolic bloodpressure at admission, serum uric acid in the comparison with good prognosis in patients andpoor prognosis is all meaningful (p＜0.05).The averages of uric acid in the good group issignificantly higher than the poor prognosis group, indicating that uric acid in favor of goodshort-term clinical outcomes of patients, and by comparison, patient age, history of atrial fibrillation, previous stroke history, admission systolic blood pressure is a risk factor for poorprognosis.2. In Patients with acute cerebral infarction,there were significantly increased SUAconcentration in male patients,Smoking history, Drinking History, History of heart diseaseand hypertension (p respectively as0.000,0.000,0.000,0.008,0.003).But the UA levelsshowed no significant difference in the distribution of the AF group, diabetes group, previousstroke history group, admission systolic blood pressure (high) group, high cholesterol group,(P)>0.05.3. To investigate the relationship between serum uric acid with different concentrationsdischarged outcome，according to quartiles of serum uric acid concentrations were dividedinto four groups.The admission SUA levels were usually in the lowest Quarter for patientswith worse prognosis (P=0.003).4. After adjustment for multivariate by logistic regression analysis, systolic bloodpressure,previous history of stroke,age were predictors for poor clinical outcomes in patientswith acute cerebral infarction，but Odds ratio of the prognosis at discharge for admissionSUA(0.996) was still significant,95%CI (0.994-0.995) P=0.01, Uric acid is a protectivefactor in patients with acute cerebral infarction in the short-term prognosis.[Conclusions]1. Serum uric acid levels for short-term clinical outcomes in patients with acute cerebralinfarction is beneficial.2.Eld, relapsing of stroke, high systolic blood pressure on admission for short-termclinical outcomes in patients with acute cerebral infarction is detrimental.