Expression And Clinical Application Of COX-2 And NCoA5 In Lymph Node Metastasis Of Papillary Thyroid Carcinoma

Objective:To explore an enzyme called cyclooxygenase 2(cox-2)and nuclear receptor activation factor 5(NCOA5)expression patterns of lymph node metastasis in papillary thyroid carcinoma and to determine its significance to the prediction of thyroid papillary carcinoma,lymph node metastasis,and to explore the preoperative can determine thyroid nodule properties of sensitive and specific factors,so that accurate assessment of the nature of thyroid nodule,can better guide the patient’s next management to guide clinical treatment accurately.Methods:1.Clinical,imaging and pathological data of patients who underwent surgical treatment for thyroid nodule in the First Hospital of Shanxi Medical University in 2019 were collected for statistical analysis.2.Immunohistochemical staining of COX-2 and NCo A5 was performed on postoperative paraffin and cell wax samples of the patients to analyze the relationship between them and cervical lymph node metastasis..Results:Univariate chi-square test and multivariate logistic regression analysis showed that positive expression of COX-2 in cancer cells,negative expression of NCOA5 in cancer cells and abnormal peripheral blood flow signals in cervical ultrasound imaging were independent risk factors for cervical lymph node metastasis.In the papillary thyroid carcinoma group and nodular goiter group,gender,thyroid stimulating hormone(TSH > 1.34),mental and life stress factors were significantly increased in the two groups.Whether the aspect ratio of nodules in ultrasound imaging is > 1.The edge of nodules is irregular;In liquid based cytology,there were statistically significant differences in the overlapping and crowded arrangement of follicular epithelial cells(P < 0.05).There was statistically significant difference in age distribution(t=-4.415,P < 0.001).Conclusion:Immunohistochemical results of COX-2 and NCOA5 and abnormal peripheral blood flow signals in ultrasound imaging can be used to predict cervical lymph node metastasis of papillary thyroid carcinoma.Liquid based cytology shows that the follicular epithelial cells are overlapping and crowded,which can be used to evaluate the nature of thyroid nodules preoperatively and thus reduce unnecessary surgical treatment.Mental life stress is closely related to papillary thyroid cancer patients,which can be advocated to improve lifestyle and reduce stress.