Clinical Observation Of Taohong Siwu Decoction Combined With Traditional Chinese Medicine Bath In The Treatment Of Biood Stasis Psoriasis

Objective:The purpose of this research is to examine the improvement degree of skin lesions of patients with blood stasis psoriasis treated by oral Taohong Siwu Decoction combined with traditional Chinese medicine bath,as well as the recurrence rate and adverse reactions after treatment,and estimate the curative effect of Taohong Siwu Decoction combined with traditional medicine bath,so we can explore an effective way of internal and external treatment of blood stasis psoriasis.Methods:The patients with psoriasis treated in our hospital were initially selected,and then 90 patients with blood stasis syndrome were selected and randomly divided into three groups,30 cases in each group.The treatment group was treated with modified Taohong Siwu Decoction Combined with traditional Chinese medicine bath,the control group was treated with modified Taohong Siwu Decoction alone,and the control group only need traditional Chinese Medicine bath every night.Every cycle of treatment is 4 weeks,a total of 2 cycles.The skin lesion area,TCM syndrome,quality of life and pruritus score of the three groups were recorded after one and two courses of treatment.Meanwhile,the recurrence rate of 1 month and 2 months after the treatment was observed.In order to ensure the safety of this study,blood collection before and after the experimental baseline to evaluate the liver and renal functions,as well as blood and urine routine.The data were analyzed by SPSS 25.0.Results:(1)PASI score:at the end of 4 weeks,there was no obvious difference between the three groups(P>0.05);at the end of 8 weeks,the PASI score of the treatment group was evidently lower than that of the two control groups(P<0.05);after 2 courses of treatment,the score of the three groups was evidently lower than that of the former(P<0.01),indicating that the three treatment methods can improve the erythema,infiltration and scale of the patients.(2)Pruritus score:after 4 weeks and 8 weeks,the improvement of pruritus symptoms was not significant(P>0.05);within the group,the transformation is clear(P<0.05).(3)Efficacy analysis:at the end of the fourth week,the effective rates of the three groups were 64.51%,53.57%,41.38%,with no significant difference(P>0.05);after 8 weeks of treatment,the effective rate was as high as 90.32%,which was more higher than 75.00%and 62.07%of the control group(P<0.05).After comparison,there were disparities between the three groups(P=0.030<0.05,P=0.013<0.05),but there was no significant difference between the control group(P=1.000>0.05),indicating that the combination therapy is better than the single group.(4)Comparison of DLQI:there was no clear difference in DLQI score among the three groups at the end of 4 weeks(P=0.707>0.05);there was a markedly difference among the groups at the end of 8 weeks(P=0.032<0.05),and the score of treatment group and control group 1 decreased significantly(P=0.043<0.05),Compared with the treatment group,the score of control group 1 did not decrease significantly(P=0.120>0.05);the quality of life improved significantly at the end of 4 and 8 weeks after treatment(P=0.000<0.05).(5)TCM syndrome score:at the end of 4 weeks,there was no obvious distinction between the three groups(P=0.295>0.05).At the end of 8 weeks,they show a difference between the treatment group and the control group 2(P=0.014<0.05),but the difference between the treatment group and the control group lwas not significant(P=0.091>0.05).(6)Comparison of patients with recurrence:after 1 month and 2 months,the relapses rate of the treatment group was slightly less in the sensualit than the control group,however,there is little difference between them(P=0.435>0.05,P=0.212>0.05).(7)PASI response rate:compared with the three groups,it had not a apparent otherness in the response rate of PASI 75 in the three groups after 4 weeks;the response rate of the treatment group was significantly higher than that of the two control groups after 8 weeks(P=0.013<0.05,P=0.010<0.05),and the two control groups were almost the same(P=0.928>0.05).Conclusion:Oral Taohong Siwu Decoction Combined with traditional Chinese medicine bath in the treatment of blood stasis psoriasis has definite curative effect,which can effectively improve the lesion area and infiltration of patients,and the rate of reaching the standard has increased substantially better than that of oral Chinese medicine alone and external use,with high safety.