| Purpose: To observe the clinical efficacy of acupuncture point paste combined with nourishing Yin and benefiting Qi method group formula in the treatment of Parkinson’s disease Qi-Yin two deficiency type constipation.Methods: 1.A total of 60 cases were selected from patients who visited the inpatient department of Jiangxi Provincial Hospital of Traditional Chinese Medicine between September 2018 and December 2020 and also met the Chinese and Western medical diagnostic criteria for Parkinson’s disease qi-yin two deficiency type constipation,as well as the inclusion criteria and exclusion criteria.The selected 60 patients were divided into observation and control groups by computerized random grouping method,with 30 patients in each group(one male patient was shed in each of the observation and control groups due to lost visits,and 29 cases in each of the two groups were included in the statistical analysis).t-test for age,duration of constipation,levodopa equivalent dose,χ2 test for gender,Fish exact probability method for underlying disease,and H-Y classification were performed for the data of both groups The rank sum test was performed,and the six aspects of clinical data(age,H-Y classification,duration of constipation,gender,underlying disease,and levodopa equivalent dose)were comparable between the two groups by statistical analysis(P > 0.05).2.In the observation group,the group was treated orally with the group formula of nourishing Yin and benefiting Qi method and conventional western medicine for anti-Parkinson’s disease with external acupuncture point application,and in the control group,the group was treated orally with conventional western medicine for anti-Parkinson’s disease and lactulose oral solution,and both groups were treated continuously for14 days.Patients in both groups were instructed to use conventional drugs to control blood lipids,blood pressure and other pre-existing underlying diseases during the treatment period,not to take other oral laxatives and not to change their diets and habits during the treatment period,and to use topical laxatives to lactate if the patient’s stool remained unresolved for more than 5 days during the treatment period.3.Pre-treatment and 2-week post-treatment scores of the selected CSS were used to assess the efficacy of constipation symptoms between and within the two groups of patients before and after treatment,the PDQ39 and the PAC-QOL was used to assess the quality of life between and within the two groups.Safety evaluation was also performed for both groups.4.The chi-square test was used for the count data;the mean±standard deviation was used for the measurement data,the paired t-test was used for the intra-group differences,and the independent sample t-test was used for the inter-group differences;the rank sum test was used for the rank data.Statistical differences were expressed as P > 0.05,and statistically significant differences were expressed as P < 0.05.The software SPSS25.0 was selected for statistical analysis of the above statistical data.Results: 1.Comparing the efficiency of constipation in the two groups after 14 days of treatment,0 cases in the observation group were cured,9 cases were effective,16 cases were effective,4 cases were invalid,the total efficiency was 86.2%;0 cases in the control group were cured,3 cases were effective,19 cases were effective,7 cases were invalid,the total efficiency was 75.9%;P-value 0.31,the total efficiency of the observation group was higher than that of the control group,but the statistical difference between the total efficiency of the two groups was not significant(P > 0.05).2.Comparing the CSS scores of the two groups before treatment and after 14 days of treatment,the CSS score of the observation group was16.97±5.55 before treatment and decreased to 8.41±5.00 after 14 days of treatment,t-value 7.84,P-value 0.00<0.05,statistically significant difference between the groups;the CSS score of the control group was 17.21±4.08 before treatment and changed to 11.34±5.14 after14 days of treatment,t-value 7.95,P-value 0.00<0.05,statistically significant difference between the groups.7.95,P-value 0.00<0.05,statistically significant difference between groups;t-value 1.89,P-value 0.85>0.05,statistically insignificant difference between groups before treatment;t-value 2.20,P-value 0.03<0.05,statistically significant difference between groups after 14 days of treatment.3.Comparing the TCM evidence points scores of the two groups before treatment and after 14 days of treatment,the observation group had 22.07±2.43 before treatment and decreased to 10.74±1.56 after treatment,t-value 23.54,P-value 0.00<0.05,statistically significant difference between the groups;the control group had 22.10±1.52 before treatment and decreased to 14.72±1.71 after treatment,t-value 21.83,P-value 0.00< 0.05,statistically significant difference in intra-group comparison;t-value 0.65,P-value 0.95 > 0.05,statistically insignificant difference in inter-group comparison between the two groups before treatment;t-value 9.32,P-value 0.00 < 0.05,statistically significant difference in inter-group comparison between the two groups after 14 days of treatment.4.Comparing the PDQ39 scores of the two groups before treatment and after 14 days of treatment,the observation group had 36.69±10.98 before treatment and decreased to 35.83±10.81 after treatment,t-value 1.84,P-value 0.76>0.05,there was no statistically significant difference between the groups;the control group had 35.97±11.88 before treatment and decreased to 35.48±12.18 after 14 days of treatment In the control group,the t-value was 2.00,P-value 0.55>0.05,and there was no statistically significant difference between the two groups before treatment.5.Comparing the PAC-QOL scores of the two groups before treatment and after 14 days of treatment,the observation group had 71.21±8.93 before treatment,which decreased to 51.62±9.73 after treatment,t-value39.56,P-value 0.00<0.05,statistically significant difference between the groups;the control group had 71.14±8.31 before treatment,which changed to 57.76±8.56 after 14 days of treatment The t-value was 29.34,P-value 0.00 < 0.05,and there was a statistically significant difference in the intra-group comparison;the t-value was 0.30,P-value 0.98 > 0.05,and there was no statistically significant difference in the inter-group comparison between the two groups before treatment;the t-value was 2.55,P-value 0.01 < 0.05,and there was a statistically significant difference in the inter-group comparison between the two groups after 14 days of treatment.6.2 cases of abdominal distension and 1 case of abdominal pain adverse drug reaction events occurred in the safety evaluation of patients in the control group during the study,and no adverse reaction events occurred in the observation group,suggesting that the safety of nourishing yin and benefiting qi method group formula combined with acupressure for PD constipation is good.Conclusion: 1.Nourishing Yin and Beneficial Qi method combined with acupoint compress and lactulose oral solution can improve constipation symptoms and constipation-related quality of life in PD patients with Qi and Yin deficiency constipation,and the former is better than the latter in improving the quality of survival,drug sensitivity,and less recurrence of constipation in patients with constipation.2.The combination of acupuncture point for patching and nourishing Yin and benefiting Qi method group did not improve the overall quality of life of PD patients,but significantly improved the TCM symptoms of constipation,and was superior to lactulose oral solution.3.The combination of the formula of nourishing Yin and benefiting Qi method to acupuncture point compression is safe in the treatment of PD patients with Qi and Yin deficiency type constipation,and it is worthy to be promoted in clinical use. |
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