| Purpose1.To investigate the distribution of TCM syndrome types in patients with chronic heart failure.2.To observe the clinical effect of Jianxin decoction on patients with chronic heart failure(Qi deficiency and blood stasis syndrome)and its effect on inflammatory factors TNF-α and ICAM-1.MethodThis study is divided into two parts: 1.The first part of the investigation: 148 patients with chronic heart failure were investigated,and the general conditions of the patients,such as sex,age,course of disease,etiology,cardiac function,TCM syndrome types and so on,were collected to explore the distribution of TCM syndrome types in patients with chronic heart failure.to study the relationship between the distribution of TCM syndrome types and influencing factors.2.The second part of clinical observation: 68 patients with chronic heart failure due to qi deficiency and blood stasis were randomly divided into control group(n = 34)and treatment group(n = 34).The former was treated with anti-heart failure drugs(controlling symptoms and treating primary disease).The latter was treated with Jianxin decoction on the basis of western medicine treatment,one dose a day,warm in the morning and evening,all around for a course of treatment.The changes of cardiac function,TCM syndrome score,TCM syndrome effect,left ventricular ejection fraction(LVEF),six-minute walking distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-pro BNP),tumor necrosis factor-α(TNF-α)and intercellular adhesion molecule-1(ICAM-1)were statistically analyzed before and after treatment.Bear fruitSurvey results: 1.Distribution of TCM syndrome types: patients with qi deficiency and blood stasis syndrome accounted for 57.43%,patients with qi-yin deficiency and blood stasis syndrome accounted for 23.65%,patients with yang-qi deficiency and blood stasis syndrome accounted for 18.92%,and patients with qi deficiency and blood stasis syndrome accounted for the largest proportion.2.The distribution of TCM syndrome types and general conditions: the distribution of TCM syndrome types was not related to sex(P > 0.05),but correlated with age,course of disease,etiology,classification of heart failure and classification of cardiac function(P< 0.01).Clinical observation: 1.comparison of NYHA cardiac function: the total effective rate of the treatment group was 88.24%,and that of the control group was 67.65%.There was significant difference between the treatment group and the control group(P< 0.05).2.TCM symptom score: after treatment,the TCM syndrome score of the treatment group and the control group decreased significantly compared with that before treatment(P < 0.01).The TCM syndrome score of the treatment group decreased more significantly than that of the control group(P < 0.05).3.Comparison of the curative effect of TCM symptoms: the total effective rate of the treatment group was85.29%,and that of the control group was 58.82%.After treatment,the curative effect of TCM symptoms in the treatment group was better than that in the control group(P< 0.05).4.The levels of LVEF and 6MWD in the treatment group and the control group after treatment were significantly higher than those before treatment(P < 0.01),and those in the treatment group were significantly higher than those in the control group after treatment(P < 0.01).5.Comparison of NT-pro BNP,TNF-α and ICAM-1: there were significant differences between the two groups after treatment(P < 0.01),and the decrease of NT-pro BNP in the treatment group was better than that in the control group(P < 0.05).The levels of TNF-α and ICAM-1 in the treatment group were significantly lower than those in the control group(P < 0.01).ConclusionInvestigation and analysis: 1.Qi deficiency and blood stasis syndrome accounts for the largest proportion in patients with chronic heart failure.2.Gender does not affect the distribution of TCM syndrome types,but age,course of disease,etiology,classification of heart failure and cardiac function classification affect the distribution of TCM syndrome types of heart failure.Clinical observation: 1.Jianxin decoction can significantly improve the cardiac function of patients with heart failure.2.Jianxin decoction can reduce the score of TCM symptoms,improve the curative effect of TCM symptoms and improve the clinical symptoms.3.Jianxin decoction can increase the level of LVEF,prolong the level of6 MWD and decrease the level of NT-pro BNP.4.Jianxin decoction can inhibit inflammatory reaction and reduce the content of TNF-α and ICAM-1 in patients. |
PDF Full Text Request