| Objective: To explore the therapeutic effect of nourishing blood,dispeling wind and relieving itching combined with emestine in the treatment of blood deficiency and wind-induced allergic conjunctivitis,and to observe its effectiveness,recurrence rate and safety,so as to provide scientific basis for nourishing blood,dispeling wind and relieving itching combined with emestine in the treatment of blood deficiency and wind-induced allergic conjunctivitis.Methods: The clinical study was divided into two aspects: therapeutic study and recurrent study.Therapeutic research,adopts the method of parallel and completely randomized clinical trial,90 patients with blood deficiency type raw wind irritability conjunctivitis were divided into control group and treatment group 45 cases,control group to in accordance with the beautiful eyes sting eye drops point,the treatment group based on the method of nourishing blood functions of relieving itching under the principles of treatment with traditional Chinese medicine internal medicine,the joint in the westin eye drops treatment,1week/treatment,after four course of medication,observe two groups in the form of scoring eye symptoms,signs and the tendency of the total score and contrast;Recurrent study: The patients were followed up for 3 months after 4 weeks of medication,and the number of recurrence and the ocular conditions of the patients in both groups were observed.Safety: evaluate the safety of medication,immediately judge the condition of adverse reactions,give positive treatment and consider whether to continue to participate in the study.Results: Therapeutic study: 1.Gender,P= 0.745> 0.05;2.For age,P=0.572 >0.05;In the course of disease,P=0.794 BBB 0 0.05.Comparison before treatment:in terms of symptoms,the difference between the two groups was P=0.763,P=0.952,P=0.859,and P=0.687 in total symptom score,both > 0.05.In terms of physical signs,compared between the two groups,the differences in conjunctival congestion(P=0.800),conjunctival edema(P=0.773),conjunctival papilla(P=1.000),limbal Horner-Trantas nodules(P=0.831),corneal epithelial lesions(P=0.992),and total sign score(P=0.662)were all > 0.05.It indicated that the general condition and pre-treatment condition of the two groups were basically similar.2.Within the group,1,2 and 4 weeks after treatment compared with before treatment,the scores of the above clinical observation indexes and the total eye score of the symptoms and signs of the two groups were lower than those of the last treatment,and showed a general downward trend.In terms of symptoms,compared with before treatment,itching(P=0.041),foreign body sensation(P=0.038),conjunctival sac secretion(P=0.039)and total symptom score(P=0.037)were all lower than 0.05 in the treatment group after 1 week of treatment,and the differences were significant.Compared with before treatment,the symptom score and symptom total score of the control group at the first week showed that eye itching(P=0.283),foreign body sensation(P=0.291),conjunctival sac secretion(P=0.209)and symptom total score(P=0.263)were all > 0.05,suggesting little difference.Compared with before treatment,eye itching(P=0.046),foreign body sensation(P=0.031),conjunctival sac secretion(P=0.028)and symptom total score(P=0.030)in the control group at week 2 were all < 0.05,and the differences were significant.In terms of physical signs,there were no significant differences in conjunctival congestion(P=0.189),conjunctival edema(P=0.192),conjunctival papilla(P=0.133),limb Horner-Trantas nodules(P=0.147),corneal epithelial lesions(P=0.216)and total sign score(P=0.180)in the treatment group after 1 week of treatment compared with before treatment.Conjunctival congestion(P=0.017),conjunctival edema(P=0.018),conjunctival papilla(P=0.020),limbus Horner-Trantas nodules(P=0.023),corneal epithelial lesions(P=0.021)and total sign score(P=0.014)were all lower than 0.05,and the differences were significant.In the control group,conjunctival hyperemia was observed 1,2 weeks after treatment(P=0.246;P=0.089),conjunctival edema(P=0.251;P=0.090),conjunctival papilla(P=0.281;P=0.130),the Horner-Trantas nodules of the limb of the cornea(P=0.283;P=0.141),corneal epithelial lesions(P=0.310;P=0.136)and the overall score of physical signs(P=0.269;P=0.086).Compared with before treatment,conjunctival hyperemia(P=0.026),conjunctival edema(P=0.031),conjunctival papilla(P=0.029),limb Horner-Trantas nodules(P=0.030),corneal epithelial lesions(P=0.028)and total sign score(P=0.022)were all lower than0.05 at week 4,showing significant differences.3.Comparison of symptoms,signs and total eye score of the two groups at week 1: P=0.555,0.578,0.594,> 0.05,there was no significant difference.At week 2,P=0.014,0.013,0.021,all < 0.05,the difference was significant.After 4 weeks,the effective number of the treatment group was 41,accounting for 93.18%,16.44% higher than that of the control group(P < 0.05).Recurrent study: Patients in the two groups were followed up for 3 months after medication.The scores of eye symptoms in the two groups were compared,and the differences were P=0.016,0.019,0.027,respectively.The differences in scores of various physical signs were P=0.021,0.026,0.027,0.020,0.025,respectively.Total eye symptom score,total sign score and total eye score were compared,P=0.002,0.000,0.000,all < 0.05,the difference was significant.The number of patients with recurrence in the treatment group was 6,accounting for13.64% of the total number of patients,and the number of patients with recurrence in the control group was 28,accounting for 65.12% of the total number of patients,the difference between the two was statistically significant(P < 0.05).Safety results: 1 case of dry eyes in the treatment group and 1 case of gastrointestinal discomfort in the control group.Conclusion: 1.Nourishing blood,dispelling wind and relieving itching combined with emestine is effective in the treatment of blood deficiency and wind-induced allergic conjunctivitis,and it is more effective than emestine alone.2.The treatment of nourishing blood,dispelling wind and relieving itching combined with emestine can reduce recurrence to a certain extent and alleviate ocular symptoms and signs after recurrence;3.The treatment of nourishing blood,dispelling wind and relieving itching combined with emestine has less adverse reactions,high safety and is worthy of clinical application. |
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