Association Of ENaC A663T Gene Polymorphism With Sudden Sensorineural Hearing Loss

Objective: To explore the potential association between ENaC A663 T gene polymorphism and sudden sensorineural hearing loss(SSNHL).Methods: Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was used to analyze the distribution of ENaC A663 T polymorphism genotype and allele frequency in 112 patients with SSNHL(20 cases of the low frequency type,19 cases of the high frequency type,31 cases of the all frequency type,and 42 cases of the profound deafness type)and 115 normal controls.Results: The T663 allele was significantly associated with increased risk of the low frequency type(P = 0.046,OR = 2.16,95% CI = 1.01-4.62).On the other hand,the TT genotype and T663 allele conferred a protective effect for the profound deafness type(AA vs.TT: P=0.012,OR = 0.25,95% CI = 0.08-0.74;A vs.T: P=0.001,OR = 0.36,95% CI = 0.21-0.61).However,there was not significant difference in genotype frequency and allele frequency between the two groups(the high frequency type and the all frequency type)and the control group.Conclusions:The ENaC A663 T gene polymorphism plays different roles in different types of SSNHL.