Clinical Observation On The Treatment Of Compensated Hepatitis B Liver Cirrhosis(Damp-heat Accumulation Syndrome) By No.2 Decoction

Objective:Observe the clinical efficacy of liver cirrhosis No.2 prescription in the treatment of patients with compensatory hepatitis B cirrhosis of damp-heat accumulation,and conduct safety assessment to provide more effective treatment ideas and clinical basis for patients with hepatitis B cirrhosis.Methods:A collection of 72 patients diagnosed with compensatory hepatitis B cirrhosis in the outpatient and inpatient department of the Department of Hepatology of Chongqing Traditional Chinese Medicine Hospital from June 2019 to July 2020,with syndrome differentiation of damp-heat accumulation syndrome,were randomly divided into treatment groups of36 cases.There were 36 cases in the control group.Patients in the control group took orally entecavir dispersible tablets,and the patients in the treatment group took entecavir dispersible tablets combined with traditional Chinese medicine decoction liver cirrhosis No.2 prescription.A 24-week clinical efficacy observation was carried out.Recorded in terms of platelet(PLT),APRI score,liver fiber(HA,LN,PⅢNP,CⅣ),liver stiffness value(LSM),TCM syndrome score,etc.at 0,12,and 24 weeks respectively,and at the same time in treatment Monitor the patient’s blood,urine,stool routine and vital signs before and after,and record in detail the adverse reactions that occurred during the course of treatment.Use SPSS 23.0 statistical package for statistical analysis.Data processing adopts chi-square test and t-test according to different conditions of count and measurement data,and repeated measurement analysis of variance is used for comparison at different time points.Results:1、Comparison of total effective rate: after 12 weeks of treatment,3cases were markedly effective in the control group,5 cases were effective,and the total effective rate was 25%;the treatment group was markedly effective in 6 cases,and 10 cases were effective,and the total effective rate was 48.49%;after 24 weeks of treatment,4 cases were markedly effective in the control group,13 cases were effective,with a total effective rate of 53.13%,and 14 cases in the treatment group were markedly effective,with 13 cases effective,with a total effective rate of81.82%.The effective rate difference between the two groups was statistically significant(p<0.05).2 、 Comparison of TCM syndrome scores: Compared with before treatment,the TCM syndrome scores of the two groups of patients decreased after 12 and 24 weeks of treatment,and the difference was statistically significant(p<0.05);compared at the same time point,the TCM syndrome scores of the treatment group The improvement was better than the control group,and the difference was statistically significant(p<0.05);and the curative effect increased with the increase of treatment time.3、Comparison of platelets: Compared with before treatment,the PLT of the treatment group increased after 12 and 24 weeks of treatment,and the difference was statistically significant(p<0.05);the control group had increased PLT after 12 and 24 weeks of treatment,and there was no difference.Statistical significance(p>0.05).Comparing the groups at the same time point,the treatment group increased significantly compared with the control group,and the difference was statistically significant(p<0.05).4、Comparison of APRI: Compared with the APRI of the control group,there is no significant difference between the treatment group and the control group after 12 weeks of treatment(p>0.05),and there is a significant difference at 24 weeks(p<0.05).5、Comparison of the four items of liver fibrosis: Compared with before treatment,the levels of serum liver fibrosis indexes HA,LN,PⅢNP and C Ⅳ of the two groups of patients decreased,and the difference was statistically significant(p<0.05);treatment for 12 and 24 weeks After comparison between the groups,the serum levels of HA,LN,PⅢNP and CⅣ in the treatment group were significantly lower than those in the control group,and the difference was statistically significant(p<0.05);and with the extension of treatment time,24 weeks was more significant than 12 weeks.The difference was statistically significant(p<0.05).6、Comparison of Fibro Scan: Compared with before treatment,the LSM of the two groups of patients decreased,and the difference was statistically significant(p<0.05);after 12 and 24 weeks of treatment,the LSM decreased level of the treatment group was lower than that of the control group.Significant,the difference was statistically significant(p<0.05);and with the extension of treatment time,24 weeks was more significant than 12 weeks,and the difference was statistically significant(p<0.05).Conclusions:The liver cirrhosis No.2 prescription has a good clinical effect in the treatment of patients with compensatory hepatitis B liver cirrhosis and damp-heat accumulation syndrome.It can significantly increase platelets,reduce APRI scores,HA,LN,PⅢNP,CⅣ levels and LSM values,and can effectively relieve at the same time Heaviness of limbs,nausea and vomiting,dry mouth and bitter mouth,yellowing of the body,fullness of the stomach and abdomen,anorexia,burning pain in the chest and flanks,uncomfortable stools,yellow urine and other clinical symptoms.In addition,during this experiment,the patient had no adverse reactions,and the safety was good.