The Distribution Characteristics Of The Constitution Of Traditional Chinese Medicine Of Prostate Cancer Patients And Correlation Analysis Between Its Risk Factors

Objective: To analyze the distribution characteristics of the constitution of traditional Chinese medicine of prostate cancer patients,and to explore its correlation with the syndrome of traditional Chinese medicine and clinical risk factors of prostate cancer patients.According to the constitution distribution characteristics,syndrome distribution characteristics and correlation analysis,from “differentiation-constitution,differrntiation-diease,differentiation-syndrome” for clinical reference to explore the prevention and treatment strategies of prostate cancer,and provide new ideas for the treatment of prostate cancer with traditional Chinese medicine.Method: Collecting prostate cancer patients who were in the oncology department and ward of First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from September 2019 to February 2021,and guide the patients to fill in the " the constitution of traditional Chinese medicine Survey Scale" and pre-designed "Prostate Cancer Patient Information Collection Form" collects general information of all patients,characteristics of the constitution of traditional Chinese medicine,the syndrome of traditional Chinese medicine and various physical and chemical indicators(TNM staging,Gleason score,prostate specific antigen,testosterone,blood lipids,etc.).Useing SPSS 22.0 to perform statistical analysis on the included information.Useing "number of cases(percent)/n(%)or composition ratio" to describe the count data,the chi-square test and Fisher’s exact test are used for comparison between groups,and the comparison of grade data between groups is used Spearman’s correlation analysis method;for measurement data that obey normal distribution.Useing mean±standard deviation analysis to describe statistics,and independent sample t test method to compare between groups;for non-normally distributed measurement data.Useing "median and Quartile range/M(QR)" to describe statistics of non-normally distributed measurement data.useing non-parametric tests(Mann-Whitney U test,Kruskal-Wallis H test)to compare between groups;Using the binary logistic regression analysis method to analyze risk factors related to different constitution fitness;Using the dimensionality reduction correspondence analysis method to analyze the correlation of related factors.Results: A total of 141 prostate cancer patients were collected in this study.The distribution of the constitution of traditional Chinese medicine: 28 are with Qi-deficiency constitution,26 with damp-heat constitution,23 with blood stasis constitution,17 with Yang-deficiency constitution,16 with phlegm-dampness constitution,and 13 with Yin-deficiency constitution,11 people are Qi-depression constitution,7 are peaceful constitution,and no one is special constitution.The distribution of the syndrome of traditional Chinese medicine: 52 patients with damp-heat accumulation syndrome,37 patients with stagnation syndrome,32 patients with Qi-deficiency and Yin-deficiency syndrome,and 20 patients with deficiency of liver-yin and kidney-yin syndrome.The age of all patients are between 48 and 93 years old,with an average age of 71.91±8.16 years old.The clinical staging distribution did not collect stage I patients,35 patients are stage II,57 patients are stage III,and 49 patients are stage IV.The combination of risk factors and statistical results showed that: the constitution of prostate cancer patients is correlated with age,smoking,drinking,Gleason score,metastasis,HDL-C,TC and other factors;It has not been found to be related with constitution are TG,t PSA,f PSA,etc.The correlation of factors such as T,BMI,LDL-C,and the risk factors of different constitution are different.The dimensionality reduction analysis results showed that there is a multi-dimensional correspondence between Constitution of traditional Chinese medicine and Syndrome of traditional Chinese medicine.Conclusions: 1.A small sample study of 141 cases showed that the characteristics of the constitution of traditional Chinese medicine distribution of prostate cancer patients in this study are: Qi-deficiency constitution is a common constitution of prostate cancer patients,while damp-heat constitution and blood stasis constitution are the more common types;2.The constitution of traditional Chinese medicine of prostate cancer patients and the syndrome of traditional Chinese medicine of them have a corresponding relationship between the types,suggesting that physique has a certain guiding effect on the formation of the syndrome of traditional Chinese medicine;3.The distribution of the constitution of traditional Chinese medicine of prostate cancer patients is shown in the correlation analysis results with clinical factors: with age,smoking,drinking,Gleason score,and metastasis,HDL-C,TC and other factors have correlation;no correlation with clinical staging,TG,t PSA,f PSA,T,BMI,LDL-C and other factors has been found,and the risk factors of different constitutions are different;4.According to collecting and sorting out the constitution of traditional Chinese medicine of prostate cancer patients,it has found that the constitutional distribution of prostate cancer patients is biased.Understanding the common biased constitution of prostate cancer patients,improving the clinical diagnosis and treatment model,and combining"precision medicine" with "adaptive measures" to correct the biased constitution.Correcting the biased constitution to achieve the Theory of“aiming for reaching balance",giving full play to the advantages of individualized treatment of traditional Chinese medicine,and provide new ideas for the clinical treatment of prostate cancer by traditional Chinese medicine.