Influencing Factors Of Non-sentinel Lymph Node Metastasis In Breast Cancer Patients With 1～2 Positive Sentinel Lymph Nodes

ObjectiveTo explore the non-sentinel lymph node(NSLN)status and the predictors of NSLN metastasis in breast cancer patients with 1～2 positive sentinel lymph nodes(SLN).MethodsThe clinicopathologic parameters of 383 breast cancer patients with1～2 positive SLNs in The First Affiliated Hospital of Chongqing Medical University from January 2016 to December 2018 were retrospectively studied.Some related predictors of NSLN metastasis were found by univariate and multivariate analysis.ResultsIn the enrolled 383 patients,only 149(38.9%)cases were observed with NSLN metastasis.Univariate analysis showed that ultrasound ALN status(P<0.001),number of positive SLNs(P=0.007),number of negative SLNs(P<0.001),Number of SLNs dissected(P<0.001),metastatic rate of SLN(P<0.001)and lymph-vascular invasion(LVI)(P= 0.003)were related with NSLN metastasis.Multivariate Logistic regressive analysis showed that ultrasound ALN status(P=0.001),number of negative SLNs(P=0.019),metastatic rate of SLN(P=0.037),LVI(P=0.039)and HER2 over-expression(P=0.026)were the independent predictive factors of NSLN metastasis.ConclusionUltrasound ALN status,number of negative SLN,metastatic rate of SLN,LVI and HER2 over-expression were the independent predictive factors of NSLN metastasis.These clinicopathological characteristics deserve our attention when decision of avoiding axillary lymph node dissection(ALND)in breast cancer patients with 1～2 positive SLNs.