| BackgroundTo investigate the value of preoperative peripheral blood lymphocyte to monocyte ratio(LMR)for early prediction of papillary thyroid cancer recurrence.Material and MethodsA retrospective study was performed to analyze the clinical and pathological data of 429 patients with thyroid papillary carcinoma.The receiver operating curve(ROC)was used to determine the optimal cut-off value for preoperative LMR to predict PTC recurrence,and patients were divided into low LMR and high LMR groups according to the optimal cut-off value,and the differences in clinical characteristics and recurrence rates between the two groups were compared.Taking the recurrence of the disease as the end event,Survival curves were plotted using the Kaplan-Meier method and log-rank tests were performed.Cox proportional hazards model were used for univariate and multivariate analyses to identify risk factors associated with PTC recurrence.To analyze the value of preoperative LMR in combination with risk stratification for predicting PTC recurrence.ResultsThe best cut-off value for preoperative LMR to predict recurrence in patients with PTC was 5.2466,with a sensitivity of 76%,a specificity of61.1%,and an area under the curve of 0.692.The recurrence rate was significantly higher in the low LMR group than in the high LMR group(11% vs 2%,P=0.000).Multifactorial analysis showed that preoperative LMR < 5.2466(P=0.006)and tumor multifocality(P=0.039)were independent risk factors for predicting PTC recurrence.The patients with preoperative LMR < 5.2466 and high risk stratification had the lowest recurrence-free survival rate and the shortest recurrence-free survival time.ConclusionPreoperative LMR is valuable for early prediction of PTC recurrence,and it can be used in clinical practice as a complement to the risk of recurrence stratification and used in combination to facilitate early detection of patients with poorer prognosis. |
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