The Correlation Between Traditional Chinese Medicine Syndrome Type And Plasma NT-proBNP In Patients With Persistent Atrial Fibrillation And Non-heart Failure

Objective: By observing the distribution of TCM syndromes in patients with permanent atrial fibrillation(AF)and non-heart failure(non-HF),and whether there are differences in TCM syndromes related to gender,age,disease duration,and combined underlying diseases,explore the correlation between TCM syndrome types and NT-proBNP for patients with permanent atrial fibrillation and non-heart failure and provide a theoretical basis for the future clinical diagnosis and treatment of the disease.Method: 159 patients with permanent AF and non-HF in the cardiology outpatient clinic and ward of the First Affiliated Hospital of Heilongjiang University of Chinese medicine from September 2018 to January 2021 were collected for this study.Detailed information of patients’ gen eral data,duration of disease,comorbid underlying conditions,TCM syndrome patterns,and NT-proBNP were recorded.The obtained data were analyzed in statistical processing.Results:1.Distribution ranking of common TCM syndrome patterns in 159 patients with permanent AF and non-HF was shown as followed: deficiency of qi and blood stasis pattern > deficiency of both qi and yin pattern >intermingled phlegm and blood stasis pattern > deficiency of heart qi pattern.2.General data and TCM syndrome pattern analysis of 159 patients with permanent AF and non-HF:(1)There was no statistical significance in each TCM pattern in terms of gender and age(P > 0.05).(2)All TCM syndromes were statistically different(P < 0.05)in terms of disease duration length.Deficiency of both qi and yin pattern had the longest average disease duration,while deficiency of qi and blood stasis pattern,deficiency of heart qi pattern,and intermingled phlegm and blood stasis pattern followed.3.Analysis of NT-proBNP,disease duration and underlying conditions in159 patients with permanent AF and non-HF:(1)For disease duration: The NT-proBNP of each stage of the disease was statistically different(P < 0.05),and the data showed that the longer the disease course was,the higher the NT proBNP value was.(2)For underlying conditions: NT-proBNP was statistically different(P< 0.05)between hypertensive blood pressure(HBP)and non-HBP patients with the same TCM syndrome pattern.None of the others were statistically different(P > 0.05).4.NT-proBNP of each TCM syndrome patterns in 159 patients with permanent AF and non-HF: The NT-proBNP level of Deficiency of both qi and yin pattern was higher than that of the other three patterns,and the difference was statistically significant(P < 0.05).No statistical significance existed in pairwise comparisons of NT-proBNP between each of the remaining syndrome patterns(P > 0.05).Conclusion:1.The common TCM syndrome patterns in 159 patients with permanent AF and non-HF were as follows: deficiency of qi and blood stasis pattern,deficiency of both qi and yin pattern,intermingled phlegm and blood stasis pattern and deficiency of heart qi pattern.Among them,deficiency of qi and blood stasis pattern accounted for the largest proportion.2.Among all the TCM syndrome patterns of 159 patients with permanent AF and non-HF,patients with deficiency of both qi and yin pattern had the longest mean disease duration and the long disease duration had a certain correlation with TCM Patterns,and the longer disease duration was associated with higher NT-proBNP levels in patients.3.NT proBNP levels of each TCM syndrome pattern in 159 patients with permanent AF and non-HF can be affected to some extent by HBP diseases.4.Among all the TCM syndrome patterns of 159 patients with permanent AF and non-HF,the NT-proBNP level of patients in deficiency of both qi and yin pattern was higher than that of the other three patterns.