An Analysis Of The Clinical Efficacy Of Dingxin Recipe In Treating Coronary Heart Disease With Permanent Atrial Fibrillation With Deficiency Of Both Qi And Yin And Blood Stasis Syndrome

Purpose:To observe the clinical efficacy and safety of jingxin prescription in the treatment of coronary heart disease(CHD)with permanent atrial fibrillation(af)and Yin deficiency combined with blood stasis.Materials and methods:According to the inclusion criteria,70 patients who visited the cardiopulmonary K outpatient department and expert outpatient department of the first affiliated hospital of liaoning university of traditional Chinese medicine from May 2018 to June 2019 were selected.The 70 patients were divided into the treatment group and the control group by random number table method in the order of treatment,with 35 patients in each group.The control group was given conventional western medicine treatment,and the treatment group was given conventional western medicine treatment plus dingxin decoction.The treatment time of both groups was 4 weeks.Observe and record 2 groups of patients before and after the treatment of ventricular rate,ecg curative effect and TCM syndrome integral,TCM syndrome curative effect,the European five-dimensional health scale(EQ-5 d),blood routine,urine routine,liver function,renal function changes of the related indicators,and after 3 months for two groups of thromboembolism in patients with follow-up,record 2 groups of patients during treatment of discomfort symptoms,presence of occurrence of adverse events.Results: 1.General information: before treatment,age,gender,disease course,combined diseases,thromboembolism risk score,and risk score of atrial fibrillation associated hemorrhage were compared between the two groups,and there was no statistical difference(P > 0.05).2.TCM syndrome score: before treatment,there was no statistically significant difference in the total score of TCM symptoms between the two groups(P > 0.05).After treatment,the score of TCM syndromes of the two groups of subjects decreased compared with that before treatment,and the differences were statistically significant(P < 0.05).After treatment,the difference of TCM syndrome score between the groups was statistically significant(P < 0.05).2.TCM syndrome efficacy: after treatment,the total effective rate of the treatment group was 90.63% and the total effective rate of the experimental group was 66.67%,with statistically significant differences(P < 0.05).3.Ventricular rate: before treatment,there was no statistically significant difference in ventricular rate between the two groups(P > 0.05).After treatment,the ventricular rate of both groups decreased,and the difference was statistically significant(P < 0.01).4.Efficacy of ventricular rate: after treatment,the total effective rate was 87.50% in the treatment group and 69.70% in the control group,and the difference was statistically significant(P < 0.05).5.Electrocardiogram efficacy: after treatment,the total effective rate in the treatment group was 31.25%,and that in the control group was 27.27%,with no statistically significant difference(P > 0.05).6.Thromboembolism status: the total incidence of thromboembolism was 3.125% in the treatment group and 3.03% in the control group after 3 months of follow-up(P > 0.05).7.European five-dimensional health scale(eq-5d): before treatment,there was no statistically significant difference in eq-5d between the two groups(P > 0.05).After treatment,the eq-5d index score of the two groups of subjects increased,and the difference was statistically significant(P < 0.01).Conclusion: 1.For patients with coronary heart disease(CHD)with permanent atrial fibrillation(af)and Yin deficiency combined with blood stasis,dingxin prescription combined with traditional western medicine can relieve their clinical symptoms of traditional Chinese medicine and reduce ventricular rate.2.For patients with coronary heart disease(CHD)with permanent atrial fibrillation(af)and Yin deficiency combined with blood stasis,centering prescription combined with western medicine can improve the quality of life of the patients 3.During the treatment and observation period,the two groups of subjects did not have serious adverse reactions,and the treatment was safe and effective,which is worthy of clinical application.