The Relationship Between Tic Disorder In Children And Serum Iron Ferritin And 25-hydroxy Vitamin D

Objective In recent years,the tic disorder(TD)in children in my country has been on the rise.At present,the pathogenesis and etiology of TD are not fully understood.The serum iron(SI),serum ferritin(SF),and serum 25-hydroxyvitamin D of children are detected.(OH)D],hemoglobin(Hb),red blood cell count(RBC),average red blood cell volume(MCV)level: 1.To explore the relationship between children’s TD and Hb,RBC,MCV,SI,SF,25(OH)D Sex,to provide a basis for exploring the pathogenesis of TD.2.Comparison of SI,SF and 25(OH)D levels in 3 different types of TD children with transient tics(TTD),chronic tics(CTD)and Tourette syndrome(TS),and understand the iron content in the body and the nutrition of vitamin D The impact of conditions on children with different types of TD provides experimental evidence for the clinical treatment and prevention of TD.3.Compare the 25(OH)D,SI,SF of children with TD in the mild group,moderate group and severe group,and speculate whether iron deficiency and vitamin D nutritional status have an impact on the severity and prognosis of TD.4.According to the Yale Tic Syndrome Overall Severity Scale(YGTSS)score,analyze whether the children’s serum SI,SF,and25(OH)D levels are correlated with the YGTSS score.Methods Through a case-control study,54 cases of TD children who were diagnosed and treated in the Department of Pediatrics of the Maternal and Child Health Hospital of Inner Mongolia Autonomous Region from January 2019 to October 2020 were selected as the observation group;54 cases of age,gender,and the observation group were selected in the same period.Normal children who came to our hospital for physical examination served as the control group.The SPSS26.0 statistical software was used to analyze the Hb,RBC,MCV,SI,SF,25(OH)D of the two groups of children.Measurement data obey normal distribution using mean±standard deviation(x±s),obey skewed distribution using median and quartile [M(P25～P75)];counting data use cases and percentage Bit [example(%)] said.The comparison between the two groups of means obeyed the normal distribution using the t test,when P<0.05,the difference was statistically significant;the comparison between the two groups of means obeyed the skewed distribution using the Mann-Whitney U test;the one-way analysis of variance was used Compare the SI,SF and 25(OH)D levels of children with different types and degrees of TD;Nemenyi test was used for pairwise comparison between groups,and the difference was statistically significant at P<0.05;Spearman was used to analyze the correlation between the 25(OH)D,SI,SF levels and YGTSS scores in the observation group,when P<0.01,The difference was statistically significant.Results 1.There was no significant difference in Hb,RBC,MCV between the two groups(P>0.05).The levels of SI,SF and 25(OH)D in the observation group were lower than those in the control group,and the difference was statistically significant at P<0.05.2.The levels of SI,SF,and 25(OH)D in children with TTD,CTD,and TS were statistically significant(P<0.05),among which children in the CTD and TS groups were SF and 25(OH).The level of D decreased more significantly than that of the TTD group(P<0.05),and the SI level of children in the TTD and TS groups was higher than that of the CTD group(P<0.05).3.There were statistically significant differences in serum 25(OH)D,SI,and SF levels in children with mild,moderate,and severe TD(P <0.05),and children with mild,moderate,and severe groups Serum 25(OH)D,SI,and SF levels showed a decreasing trend;the 25(OH)D,SI and SF levels of children in the mild group were significantly different from those in the moderate and severe groups(P <0.05));There was a statistically significant difference in 25(OH)D and SI levels between the moderate group and the severe group(P <0.05).4.Spearman correlation analysis showed that the YGTSS scale score was negatively correlated with SI,SF,and 25(OH)D levels(r=-0.481,P<0.01;r=-0.786,P<0.01;r=-0.629,P<0.01).Conclusion 1.The existence of SI,SF,25(OH)D in children with TD is related to the onset of TD,and the content of RBC,Hb,MCV has nothing to do with the occurrence of TD.2.The decrease of SI,SF,25(OH)D is related to TD classification.The level of SI,SF,25(OH)D further decreases,and children with TTD may transition to CTD and TS.3.The levels of SI,SF,and 25(OH)D in children with TD are closely related to the severity of tics.Children with severe TD have obvious hypoferemia and lack of 25(OH)D levels.25(OH)D,SI,The lower the SF level,the more obvious the symptoms of tics and the worse the condition.4.The levels of SI,SF and 25(OH)D in children with TD are correlated with the YGTSS score.