Research Of Effects Of TDCS On Working Memory Training And Neuroplasticity

Working memory is a limited cognitive system of information storage and processing in complex cognition.With the complexity and diversification of information processing and decision-making,people’s working memory ability and working memory capacity are facing challenges.It has been found that transcranial direct current stimulation(tDCS)could adjust the firing of neurons to regulate the efficiency and plasticity of neurons.However,the current studies on the cognitive enhancement of healthy people mainly focus on the immediate effect and short-term effect of tDCS,lack of systematic research on the effects of long-term cognitive training and neural mechanism.In this paper,the effects of high-definition transcranial direct current stimulation(HD-tDCS)on working memory training process,training effect and brain plasticity were studied.Firstly,this study designed and carried out the working memory training experiment under HD-tDCS(30min,2m A,anode: F3).34 subjects recruited were randomly divided into active and sham groups for 10 consecutive days of training,including adaptive task and constant task.To further explore the long-term effect of training on working memory ability and neural plasticity,working memory tests were conducted before training,one day after training,20 days after training and 90 days after training,behavioral data and electroencephalogram(EEG)were recorded during the tests.Secondly,this study analyzed the behavioral data.The results showed that the training speed and effect of the active group were significantly higher than that of the sham group.After training,the response accuracy of the active group was significantly improved,the maximum working memory capacity was significantly higher than that of the sham group,and it also improved the untrained task.It showed that HD-tDCS facilitated the training process,improved working memory ability and capacity,and the effect of training on working memory was transferred to untrained tasks.Finally,this study analyzed the event-related EEG of the tests.The analysis of event-related potential(ERP)showed that the amplitude increment of N2 component in the active group was significantly larger than that in the sham group,indicating that HD-tDCS regulated the attention level of task state.Based on the analysis of eventrelated spectrum perturbation,it was found that the event-related desynchronization decreased and the event-related synchronization increased in the active group after training,but changed in the sham group 20 days after training,indicating that HD-tDCS promoted the formation of neural plasticity.Brain network analysis showed that after training,the network connection of frontal cortex in the active group was significantly enhanced,and the global efficiency and cluster coefficient of brain were increased,which indicated that HD-tDCS improved the processing efficiency of brain interval.The results showed that HD-tDCS combined with working memory training could facilitate the training process,accelerate the neural plasticity,improve the training efficiency and enhance the training effect.The above results provided a more efficient training method for cognitive ability training such as working memory,and were expected to provide a more effective method for people with cognitive impairment to repair and remodeling.