| Object: To explore the characteristics of cervical lesions in the Shihezi region of Xinjiang in the past four years and provide guidance for clinical work and local cervical cancer screening.Methods : Selected patients who were treated at ours Hospital from May 2017 to February 2021,and found abnormal results after combined liquid-based cytology and HPV screening,and further underwent colposcopy cervical biopsy,totaling 3240 Cases,including the patient’s general information such as age,age at first sexual life,number of sexual partners,number of pregnancy and parity,as well as pathological results of TCT,HPV and cervical biopsy,retrospective analysis of the correlation between the clinical data of these patients and cervical lesions.Take histological examination as the gold standard.Results:1.Among 3109 patients with complete basic information,no school education(odds ratio,OR=5.037),irregular vaginal bleeding(OR=3.330)and the number of sexual partners≥3(OR=1.609)were independent risk factors for cervical high-grade lesions.2.In 3240 cases of patients,the result is genital warts cervical biopsy sample has 1,587 cases of inflammatory changes(48.98%),1 neoplasia grade cervical intraepithelial(cervical intraepithelial neoplasias,CIN 1)819 patients(25.28%)of CIN2 have 312 cases(9.63%),435 cases(13.43%)for CIN3,87 cases(2.69%)for cervical cancer.3.The positive rate of CIN was the highest in the 30-39 age group(57.54%),followed by the < 30 age group(57.34%),and the lowest in the ≥ 60 age group(34.91%).The detection rate of cervical cancer in ≥ 60 years old group was the highest(14.15%),followed by 40 ～ 49 years old group(2.20%),and cervical cancer patients are not detected in the 30-year-old age group.4.Among the 3240 patients collected in our study,HPV positive patients accounted for96.57%(3129),among which 906 cases were HPV16 positive(27.96%),102 cases were HPV18 positive(3.14%),and 39 cases were HPV16 and 18 double infections(1.20%),other subtypes are positive in 2145 cases(66.20%);HPV-negative population has 48 cases(1.48%).5.In the age gorup of 40 to 49,the HPV16/18 infection rate was the highest,which is39.38%.No significant difference was found in the distribution of HPV viral load in different age groups(P>0.05).6.Comparing the detection rate of HPV16/18 positive group with other HPV subtype groups,it can be seen from the table that the detection rates of CIN3 and cervical cancer of the former are higher than those of the latter,and the ratio is,18.34% vs 11.33%,4.30% vs1.82%,P values are all less than 0.05.7.In the HPV-positive population with TCT as ASC-US(816 case)and LSIL(1536cases)the detection rate of CIN3 in the HPV16/18 positive group was significantly higher than that of other HPV subtype-positive groups(ASC-US: 21.43% vs 8.33%,LSIL:18.00% vs 7.04%),the P values are 0.005 and <0.001,respectively.Conclusion:Among the research objects included in this study:1.Among 3109 patients with complete basic information,the independent risk factors for high-grade cervical lesions were: no school education(OR=5.037),irregular vaginal bleeding(OR=3.330)and ≥3 sexual partners(OR=1.609).2.Among the 3240 patients,the detection rate of CIN was the highest in the30-39-year-old age group,and the detection rate of cervical cancer was the highest in the age group ≥60 years old.3.High-risk HPV infection,especially HPV16,is closely related to the occurrence of CIN and cervical cancer in these patients.HPV infection is highest in the 40-49-year-old age group;the detection rate of HPV16/18 positive and high viral load patients with ≥CIN2is higher than that of other HPV subtype positive and low to medium load patients. |
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