Epidemiology And Relative Factors Of Infant Functional Gastrointestinaldisorders

Objective: To explore the clinical epidemiological characteristics and relative factors of infant functional gastrointestinal disorders(FGIDs),which provides a reference for clinical diagnosis and treatment of FGIDs.Methods: From October 2017 to October 2018,infants aged 0-12 months who underwent infant health examinations in Jinjiang Maternal and Child Health Care Hospital were selected as the research subjects,and the clinical investigation of infant FGIDs and the on-site questionnaire survey of related factors were conducted.Researchers conducted the symptom inquiry,physical examination,growth index measurement and necessary auxiliary examinations of these subjects,and instructed parents to fill in the questionnaire.All subjects were followed up to 1 year old.The diagnosis of infant FGIDs was performed using Rome IV criteria.Statistical analysis was performed with SPSS 23.0 software,P< 0.05 was considered statistically significant.Results:(1)A total of 1006 infants were enrolled in this study,including 549 males and457 females.According to the Rome IV standard,586(58.3%)of 1006 infants developed FGIDs.Among them,there were 460 cases(45.7%)with infant regurgitation,168 cases(16.7%)with infant dyschezia,36 cases(3.6%)with functional constipation,32 cases(3.2%)with functional diarrhea and 24 cases(2.4%)with colic.No infant rumination syndrome and cyclic vomiting syndrome were found.Among 586 infants with FGIDs,457 cases(78.0%)were single FGIDs,124 cases(21.2%)coexisted with 2types of FGIDs,5 cases(0.9%)coexisted with 3 types of FGIDs,and no infants with 4or more types of FGIDs were found.Among the 457 cases of single infant FGIDs,343cases(58.6%)were infant regurgitation,78 cases(13.3%)of infants with dyschezia,14cases(2.4%)with functional constipation,17 cases(2.9%)with functional diarrhea and5 cases(0.9%)with colic.Among the 124 infants with two types of FGIDs,the coexistence of infant regurgitation and infant dyschezia was the most common condition,there were 75 cases(12.8%).The other common conditions are the coexistence of infant regurgitation and Infant colic,the coexistence of infant regurgitation and infant functional diarrhea,and the coexistence of infantile reflux and infant functional constipation.The number of cases was 14(2.4%),12(2.0%)and 11(1.9%)respectively.(2)Taking FGIDs infants as the case group and healthy infants without FGIDs as the control group,the univariate χ2 test was performed.The results showed that family origin,father’s age,father’s FGIDs history,mother’s FGIDs history,a history of maternal pregnancy disease,vitamin D supplementation after birth and probiotics supplementation after birth were associated with infant FGIDs.The statistically significant factors selected by univariate χ2 test analysis were used as independent variables,and whether they were FGIDs infants as dependent variables,unconditional Logistics multiple regression analysis was performed.Four influencing factors associated with the development of FGIDs were screened out: the father’s young age(regression coefficient B=0.424,P=0.004),father’s FGIDs history(regression coefficient B=0.821,P=0.000),maternal FGIDs history(regression coefficient B=0.427,P=0.012),probiotics supplementation after birth(regression coefficient B=0.324,P=0.032)were the risk factors for FGIDs.The vitamin D supplementation after birth(regression coefficient B=-0.69,P=0.000)was a protective factor to avoid the occurrence of FGIDs.(3)The follow-up results showed that there was no statistically significant difference in height,weight,head circumference,hemoglobin,and eosinophils between the case group and the control group at the age of6 months and 12 months.Conclusion: The clinical incidence rate of infant FGIDs is relatively high,and some infants may be coexisting with multiple FGIDs.Young father age,father / mother’s history of FGIDs and probiotics supplementation after birth are risk factors for the occurrence of infant FGIDs,while vitamin D supplementation after birth is a protective factor to avoid infant FGIDs.FGIDs do not affect the growth and development of infants.