Relationship Between Preoperative Peripheral Blood NLR,PLR,LMR,SII,D-dimer And Clinicopathological Features And Prognosis In Patients With Epithelial Ovarian Carcinoma

Objective: To analyze the contents of NLR,PLR,LMR,SII and D-dimer in the preoperative peripheral blood of patients with epithelial ovarian cancer,and to explore their relationship with clinicopathological features and prognosis.Methods: A total of 113 cases of epithelial ovarian cancer confirmed by surgery and pathology in the Fourth Hospital of Hebei Medical University from 2015 to 2018 were collected,patients’ age,disease were retrospectively analyzed preoperative CA125 levels,ascites,satisfaction with the operation,postoperative pathologic staging,pathological type,whether lymph node metastasis,sensitive to platinum whether these data and statistical analysis of clinical features.At the same time,the ratio of Neutrophil to lymphocyte(NLR)and Platelet to lymphocyte(Platelet to lymphocyte)in peripheral blood at initial treatment were also counted.PLR),Lymphocyte to monocyte ratio(LMR),Systemic immune-inflammation Index(SII)and D-dimer content.Receiver operating characteristic curve(ROC)was plotted to determine the optimal critical values of NLR,PLR,LMR,SII and D-dimer,which were divided into two groups of high and low values.The correlation between the two groups and clinical data and its influence on prognosis were analyzed.Results:1.The contents of NLR,PLR,LMR,SII and D-dimer in preoperative peripheral blood of 113 patients with epithelial ovarian cancer were statistically analyzed,and the ROC curve was drawn,and the critical values were 2.72,215.96,3.67,1075.16 and 1.40,respectively,and were divided into two groups with high and low values.2.The comparison of the clinical data of patients with epithelial ovarian cancer between the high and the low groups showed that NLR was related to whether patients had ascites,pathological stage,postoperative residual lesion size,and whether platinum was sensitive(all P < 0.05).PLR was correlated with ascites,pathological stage,postoperative residual lesion size and platinum sensitivity(all P < 0.05).LMR was correlated with pathological types and size of postoperative residual lesions(all P < 0.05).SII was correlated with ascites,postoperative residual lesion size,pathological type and platinum sensitivity(all P < 0.05).D-dimer was correlated with preoperative CA125 level,ascites presence,pathological stage,postoperative residual lesion size and pathological type(all P < 0.05).3.In the prognostic analysis,PFS and OS in the high NLR,PLR,SII,D-dimer and low LMR groups were significantly lower than those in the control group,and the differences were statistically significant(P <0.05).Univariate analysis showed that preoperative high NLR,PLR,SII,D-dimer and low LMR were the risk factors affecting postoperative PFS and OS(P < 0.05),while preoperative age,CA125 and ascites were significantly correlated with preoperative age.There was no correlation between postoperative pathological stage,pathological type,lymph node metastasis,tumor reduction surgery and sensitivity to platinum chemotherapy(P >0.05).Multivariate results showed that high D-dimer was an independent risk factor for postoperative PFS(P < 0.05).Low LMR and high D-dimer were independent risk factors for postoperative OS(P < 0.05).Conclusion:Preoperative high NLR,PLR,SII,D-dimer and low LMR in peripheral blood are associated with poor prognosis in patients with epithelial ovarian cancer.High D-dimer and low LMR are independent risk factors affecting patients’ OS,while high D-dimer is an independent risk factor affecting patients’ PFS.